2154-37-2 Usage
Uses
Used in Neurodegenerative Disorders:
TEMPOL is used as a therapeutic agent for neurodegenerative disorders due to its ability to reduce oxidative stress and protect neurons from damage. Its antioxidant properties help in slowing down the progression of diseases such as Alzheimer's, Parkinson's, and ALS.
Used in Cardiovascular Diseases:
In the field of cardiovascular medicine, TEMPOL is utilized as a treatment to combat oxidative stress and inflammation associated with heart diseases. Its capacity to scavenge free radicals contributes to the prevention of atherosclerosis and other cardiovascular complications.
Used in Cancer Therapy:
TEMPOL is employed as an adjunct to cancer treatment, where it can enhance the effectiveness of conventional therapies and reduce the side effects caused by oxidative stress. Its anti-inflammatory and antioxidant properties aid in mitigating the damage caused by reactive oxygen species during cancer treatment.
Used in Research:
TEMPOL is used as a research tool to study oxidative stress and evaluate the efficacy of antioxidant therapies. Its stable free radical nature allows for the investigation of various biological processes and the development of new therapeutic strategies to combat diseases associated with oxidative stress.
Check Digit Verification of cas no
The CAS Registry Mumber 2154-37-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,5 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2154-37:
(6*2)+(5*1)+(4*5)+(3*4)+(2*3)+(1*7)=62
62 % 10 = 2
So 2154-37-2 is a valid CAS Registry Number.
2154-37-2Relevant academic research and scientific papers
The exchange reaction of hydrogen atoms in the system sterically hindered hydroxylamine - Nitroxyl radical
Malievskii,Koroteev
, p. 1287 - 1291 (2007/10/03)
The rate constants of the direct and reverse exchange reactions of the hydrogen atom in the system sterically-hindered nitroxyl radical - hydroxylamine of the quinoline, imidazoline, pyrrolidine, and piperidine series as well as diarylhydroxylamine were determined. A scale of the reductive abilities of the hydroxylamines was established. A low value of the isotope effect is typical of the reactions of hydrogen exchange in the systems hydroxylamine - nitroxyl radical.
INFLUENCE OF CHEMICAL STRUCTURE OF NITROXYL SPIN LABELS ON THEIR REDUCTION BY ASCORBIC ACID
Couet, W. R.,Brasch, R. C.,Sosnovsky, G.,Lukszo, J.,Prakash, I.,et. al.
, p. 1165 - 1172 (2007/10/02)
The influence of structure on the reduction of nitroxyl spin labels by ascorbic acid was examined using both piperidine and pyrrolidine nitroxyls.A five-fold molar excess of ascorbic acid and pH of 7.4 were used.The nitroxyl concentration was measured by electron spin resonance spectrometry.The five-membered (pyrrolidine) nitroxyls were more stable than the six-membered derivatives.Ring substituents also influenced the reaction.The anionic derivatives were more stable than the unionized compounds which, in turn, were more stable than the amines (cations at pH 7.4).
