21543-49-7

Basic information

• Product Name: 2-Chloro-5-hydroxymethylpyridine
• Synonyms: 2-CHLORO-5-HYDROXYMETHYLPYRIDINE;6-CHLOROPYRIDINE-3-METHANOL;(6-CHLOROPYRIDIN-3-YL)METHANOL;6-Chloro-3-(hydroxymethyl)pyridine;6-CHLORO-3-PYRIDINEMETHANOL;(6-CHLORO-3-PYRIDINYL)METHANOL;2-Chloro-2-(hydroxymethyl)pyridine;6-Chloropyridine-3-methanol,98%
• CAS NO: 21543-49-7
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: -0
• Product Categories: Pyridine;Fluorobenzene;Alcohols and Derivatives;Heterocycles;Hydroxymethyl's;Pyridines;Chloropyridines;Halopyridines;Boronic Acid;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;API Intermediate;Heterocycle-Pyridine series
• Mol File: 21543-49-7.mol
• Article Data: 40

Chemical Properties

• Melting Point: 51-54 °C(lit.)
• Boiling Point: 120°C 0,4mm
• Flash Point: >230 °F
• Appearance: White to brown/Powder or Low Melting Solid
• Density: 1.280
• Vapor Pressure: 0.00227mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 13.32±0.10(Predicted)
• BRN: 1525126
• CAS DataBase Reference: 2-Chloro-5-hydroxymethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-hydroxymethylpyridine(21543-49-7)
• EPA Substance Registry System: 2-Chloro-5-hydroxymethylpyridine(21543-49-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 21543-49-7(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H6ClNO/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2

Upstream product

• 49608-01-7 6-chloro-3-pyridinecarboxylic acid ethyl ester 
• 2953-37-9 3β,5-dihydroxy-5α-cholestan-6-one 
• 23100-12-1 6-chloronicotinylaldehyde 
• 234109-28-5 2-((6-chloropyridin-3-yl)oxy)acetic acid 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 105827-78-9 imidacloprid 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 85320-79-2 5-chloro-nicotinoyl chloride 
• 6311-35-9 6-bromonicotinic acid 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 

Downstream Products

• 101990-45-8 2-bromo-5-bromomethylpyridine 
• 748796-38-5 (6-(1H-pyrazol-1-yl)pyridin-3-yl)methanol 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 101990-67-4 6-ethoxy-3-hydroxymethylpyridine 
• 179873-48-4 2,2’-bipyridine-5-carbaldehyde 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 39977-42-9 5-hydroxymethyl-pyridine-2-carboxylic acid methyl ester 
• 1429771-02-7 2-(6-(2-(7-phenylheptanoyl)-1,3-oxazol-5-yl)pyridin-3-yl)acetonitrile 
• 1429771-05-0 2-(6-(2-(1-hydroxy-7-phenylheptyl)oxazol-5-yl)pyridin-3-yl)acetonitrile 
• 1429771-04-9 2-(6-(2-(1-((tert-butyldimethylsilyl)oxy)-7-phenylheptyl)oxazol-5-7yl)pyridin-3-yl)acetonitrile 
• 1440676-73-2 C₂₄H₃₄N₈S 
• 1440676-67-4 C₂₁H₂₇N₇S 
• 1440677-15-5 C₁₅H₁₈N₄ 
• 938435-64-4 N,N-dimethyl-4-[(E)-2-(6-chloropyridin-3-yl)vinyl]aniline 

Relevant articles and documents

Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594

A series of highly sterically hindered secondary amine analogues of pyridylmethylamine (7a-f, 8a-c) and positional isomeric analogues of ABT-594 (9a-c) were synthesized and evaluated for their in vivo analgesic activity. The compounds 7a and 7d show potent analgesic activity and lower toxicity. Some interesting structure-activity relationships have been revealed.

Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors

A broad range of chalcones and derivatives were easily and rapidly synthesized, following Claisen-Schmidt condensation of (hetero)aryl ketones and (hetero)aryl aldehydes using a ultrasound probe. A comparison was made with classical magnetic stirring experiments, and an optimization study was realized, showing lithium hydroxide to be the best basic catalyst of the studied condensations. By-products of the reactions (β-hydroxy-ketone, diketones, and cyclohexanols) were also isolated. All compounds were evaluated in vitro for their ability to inhibit human farnesyltransferase, a protein implicated in cancer and rare diseases and on the NCI-60 cancer cell lines panel. Molecules showed inhibitory activity on the target protein and cytostatic effect on different cell lines with particular activity against MCF7, breast cancer cells.

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).

SUBSTITUTED PYRIMIDINIUM COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS

The present invention relates to substituted pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these substituted pyrimidinium compounds and of compositions thereof, for combating and controlling animal pests. Furthermore the invention relates also to pesticidal methods of applying such substituted pyrimidinium compounds. The substituted pyrimidinium compounds of the present invention are defined by the following general formula (I) wherein X, Y, Z, R1, R2, A and Het are defined as in the description.