938435-64-4

Upstream product

• 23100-12-1 6-chloronicotinylaldehyde 
• 32264-24-7 diethyl 4-N,N-dimethylaminobenzylphosphonate 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 21543-49-7 2-Chloro-5-hydroxymethylpyridine 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 561066-65-7 diethyl ((6-chloropyridine-3-yl)methyl)phosphonate 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 1440677-15-5 C₁₅H₁₈N₄ 
• 1440676-67-4 C₂₁H₂₇N₇S 
• 1440676-73-2 C₂₄H₃₄N₈S 

Relevant academic research and scientific papers

METAL COMPLEXES AS IMAGING AGENTS

The present invention relates to copper, gallium and technetium coordinated thiosemicarbazone- pyridylhydrazine (substitued at the pyridine ring with a substituted benzothiazole or stilbene moiety) complexes and methods thereof. Such compounds possess utility in PET imaging and diagnosis of amyloid diseases.

Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques

One of the pathological hallmarks of Alzheimer's disease is the presence of amyloid-β plaques in the brain and the major constituent of these plaques is aggregated amyloid-β peptide. New thiosemicarbazone-pyridylhydrazine based ligands that incorporate functional groups designed to bind amyloid-β plaques have been synthesized. The new ligands form stable four coordinate complexes with a positron-emitting radioactive isotope of copper, 64Cu. Two of the new CuII complexes include a functionalized styrylpyridine group and these complexes bind to amyloid-β plaques in samples of post-mortem human brain tissue. Strategies to increase brain uptake by functional group manipulation have led to a 64Cu complex that effectively crosses the blood-brain barrier in wild-type mice. The new complexes described in this manuscript provide insight into strategies to deliver metal complexes to amyloid-β plaques.

STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES

This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making