215453-73-9

Upstream product

• 93-97-0 benzoic acid anhydride 
• 33007-09-9 furo[3,2-c]pyridin-4-ylamine 
• 26956-43-4 furo[3,2-c]pyridine-4-ol 
• 31270-80-1 4-chlorofuro[3,2-c]pyridine 

Downstream Products

• 1309048-39-2 N-{2-[3,5-dicyano-1,2,6-trimethyl-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-36-9 N-[2-(3-cyano-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridin-4-yl)furo[3,2-c]pyridin-4-yl]benzamide 
• 1309048-35-8 N-[2-(5-cyano-3,6-dimethyl-4,7-dihydro[1,2]oxazolo[5,4-b]pyridin-4-yl)furo[3,2-c]pyridin-4-yl]benzamide 
• 1309048-34-7 N-[2-(7,9-dicyano-6-methyl-1,3,4,8-tetrahydropyrido[2,1-c][1,4]oxazin-8-yl)furo[3,2-c]pyridin-4-yl]benzamide 
• 1309048-33-6 N-{2-[3,5-dicyano-2,6-bis(difluoromethyl)-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-29-0 N-{2-[3,5-dicyano-2-methyl-6-(trifluoromethyl)-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-26-7 N-{2-[3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-25-6 N-{2-[3,5-dicyano-2-(4-chlorophenyl)-6-methyl-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-24-5 N-{2-[3,5-dicyano-2-(4-fluorophenyl)-6-methyl-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-23-4 N-{2-[3,5-dicyano-2-(difluoromethyl)-6-methyl-1,4-dihydropyridin-4-yl]furo[3,2-c]pyridin-4-yl}benzamide 
• 1309048-45-0 N-{2-(2-cyano-3-oxobut-1-en-1-yl)furo[3,2-c]pyridin-4-yl}benzamide 
• 215453-75-1 2-(4-benzoylamino-furo[3,2-c]pyridin-2-ylmethyl)-2-tert-butoxycarbonylamino-malonic acid diethyl ester 
• 215453-74-0 N-(2-hydroxymethyl-furo[3,2-c]pyridin-4-yl)-benzamide 

Relevant academic research and scientific papers

AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF

The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.

FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF

This invention relates to novel 4-(furo[3,2-c]pyridin-2-yl)-l,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders

Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors

Replacement of the highly basic benzamidine moiety with moderate basic amino-bicycloaryl moieties in a series of thrombin inhibitors related to NAPAMP provided potent enzyme inhibition and significant improvements in membrane transport and oral bioavailability.