21547-96-6Relevant academic research and scientific papers
Chiral N(H)-tBu and N(H)-Ad NiII complexes of glycine schiff bases: Deduction of a mode of kinetic diastereoselectivity
Maestro, Miguel A.,Avecilla, Fernando,Sorochinsky, Alexander E.,Ellis, Trevor K.,Acena, Jose Luis,Soloshonok, Vadim A.
, p. 4309 - 4314 (2014)
The results reported herein have led to the discovery of a novel mode of kinetic diastereoselectivity in the alkylation of N-tert-butyl- and N-(1-adamanyl)-containing NiII complexes of glycine Schiff bases. It arises from a significant differen
Synthesis and evaluation of novel pyrazole-imidazole hybrids as antimicrobial candidates
Punia, Suman,Verma, Vikas,Kumar, Devinder,Kumar, Ashwani,Deswal, Laxmi,Parshad, Mahavir
, p. 2832 - 2846 (2021/07/26)
The present study describes a facile and efficient synthesis of 1-(N-arylacetamide)-4-phenyl-2-pyrazolyl-imidazole 7a–7t by reacting 1-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole (3a)/3,5-dimethyl-1-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole (3b) with 2-bromo-N-
Synthesis and antidiabetic evaluation of benzimidazole-tethered 1,2,3-triazoles
Deswal, Laxmi,Verma, Vikas,Kumar, Devinder,Kaushik, Chander?P.,Kumar, Ashwani,Deswal, Yogesh,Punia, Suman
, (2020/07/04)
Some novel benzimidazole-tethered 1,2,3-triazole derivatives (4a–r) were synthesized by a click reaction between 2-substituted 1-(prop-2-yn-1-yl)-1H-benzo[d]imidazole and in situ azide. The structures of the synthesized compounds were confirmed by spectroscopic studies (one- and two-dimensional nuclear magnetic resonance, Fourier transform infrared, and high-resolution mass spectra). The synthesized compounds were evaluated for their antidiabetic activity. Compounds 4a–r exhibited a good-to-moderate α-amylase and α-glucosidase inhibitory activity, with IC50 values ranging from 0.0410 to 0.0916 μmol/ml and 0.0146 to 0.0732 μmol/ml, respectively. Compounds 4e, 4g, and 4n were found to be most active. Furthermore, the binding conformation of the most active compounds was ascertained by docking studies.
Rapid photoassisted access to N,O,S-polyheterocycles with benzoazocine and hydroquinoline cores: Intramolecular cycloadditions of photogenerated azaxylylenes
Mukhina, Olga A.,Bhuvan Kumar,Arisco, Teresa M.,Valiulin, Roman A.,Metzel, Greg A.,Kutateladze, Andrei G.
supporting information; experimental part, p. 9423 - 9428 (2011/11/06)
Ring the changes: A new photoassisted approach to give conformationally constrained N,O,S-polyheterocyclic scaffolds of unprecedented topologies was achieved by intramolecular [4+4] and [4+2] cycloadditions of photogenerated o-azaxylylenes (23 examples; see scheme). The precursors can be readily assembled by simple and high-yielding reactions, thus making this a powerful synthetic method amenable to high-throughput diversity-oriented synthesis.
Design, synthesis, and evaluation of a new generation of modular nucleophilic glycine equivalents for the efficient synthesis of sterically constrained α-amino acids
Ellis, Trevor K.,Ueki, Hisanori,Yamada, Takeshi,Ohfune, Yasufumi,Soloshonok, Vadim A.
, p. 8572 - 8578 (2007/10/03)
A new generation of modular achiral glycine equivalents have been evaluated with respect to their synthetic utility for the production of tailor-made, sterically constrained α-amino acids, which proved to be the most efficient approach developed to date for the synthesis of symmetrical α,α-disubstituted-α-amino acids. Among the new series of achiral glycine equivalents, one was found to be a superior glycine derivative for the Michael additions with various (R)- or (S)-N-(E-enoyl)-4-phenyl-1,3- oxazolidin-2-ones representing a general and practical synthesis of sterically constrained β-substituted pyroglutamic acids. In particular, the application of these complexes allowed for the preparation of several β-substituted pyroglutamic acids which include electron-releasing and sterically demanding substituents in the structure thus increasing the synthetic efficiency and expanding the generality of these Michael addition reactions.
