21550-86-7

Basic information

• Product Name: 1,2,3,3A-TETRAHYDRO-5H-PYRROLO[1,2-A]QUINOXALIN-4-ONE
• Synonyms: 1,2,3,3A-TETRAHYDRO-5H-PYRROLO[1,2-A]QUINOXALIN-4-ONE;AKOS AL-22;1,2,3,3a-Tetrahydropyrrolo-[1,2-a]quinoxalin-4(5H)-one
• CAS NO: 21550-86-7
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.23
• Mol File: 21550-86-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3,3A-TETRAHYDRO-5H-PYRROLO[1,2-A]QUINOXALIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,3A-TETRAHYDRO-5H-PYRROLO[1,2-A]QUINOXALIN-4-ONE(21550-86-7)
• EPA Substance Registry System: 1,2,3,3A-TETRAHYDRO-5H-PYRROLO[1,2-A]QUINOXALIN-4-ONE(21550-86-7)

Safety Data

• Hazardous Substances Data: 21550-86-7(Hazardous Substances Data)

Usage

Chemical structure

THPQ is a heterocyclic compound with a fused pyrrolidine and quinoxaline ring structure.

Biological activities

THPQ exhibits various biological activities, including anticonvulsant and analgesic properties.

Potential drug candidate

THPQ has been studied for its potential as a drug candidate for the treatment of neurological disorders and as an analgesic agent.

Medicinal chemistry research

THPQ's unique structure and pharmacological activities make it a subject of interest for medicinal chemistry research and drug development.

Organic synthesis

THPQ has been investigated for its potential in the field of organic synthesis.

Building block for new chemical entities

THPQ is considered as a building block for the development of new chemical entities.

Molecular weight

The molecular weight of THPQ is not provided in the material, but it can be calculated based on its chemical formula and the atomic weights of the constituent elements.

Solubility

The solubility of THPQ in various solvents is not mentioned in the material, but it can be inferred that its solubility may depend on the specific functional groups present in its structure.

Stability

The stability of THPQ under different conditions (e.g., temperature, pH, etc.) is not provided in the material, but it can be assumed that its stability may be influenced by its chemical structure and the presence of functional groups.

Upstream product

• 89860-72-0 7-Amino-1,2,3,3a-tetrahydro-5H-pyrrolo[1,2-a]quinoxalin-4-one 
• 89860-66-2 1-(2-Nitro-phenyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 31981-54-1 (S)-N-(2-nitrophenyl)proline 
• 31981-54-1 N-(2-nitrophenyl)-DL-proline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 609-36-9 rac-Pro-OH 
• 88-73-3 2-Chloronitrobenzene 
• 147-85-3 L-proline 
• 84831-77-6 1,2,3,3a-tetrahydro-7-nitropyrrolo<1,2-a>quinoxalin-4-one 
• 615-36-1 2-bromoaniline 

Downstream Products

• 91623-03-9 1,2,3,3a-tetrahydro-5-(phenylmethyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one 
• 91623-05-1 1,2,3,3a,4,5-hexahydro-5-[(2,6-dimethoxyphenyl)methyl]pyrrolo[1,2-a]quinoxaline 
• 91623-02-8 5-(2,6-dimethoxybenzoyl)-1,2,3,3a,4,5-hexahydropyrrolo<1,2-a>quinoxaline 
• 92622-53-2 1,2,3,3a,4,5-hexahydropyrrolo<1,2-a>quinoxaline 
• 91623-04-0 5-<(2,6-dimethoxyphenyl)methyl>-1,2,3,3a-tetrahydropyrrolo<1,2-a>quinoxalin-4(5H)-one 

Relevant articles and documents

Practical synthesis of quinoxalinones via palladium-catalyzed intramolecular N-arylations

A practical and highly efficient route to the synthesis of pharmaceutically interesting quinoxalinone scaffolds is reported. The key step involves an intramolecular palladium-catalyzed N-arylation under microwave irradiation. The developed methodology tolerates a variety of bromoanilides to afford a diverse collection of bicyclic and polycyclic quinoxalinones in high yield.

Synthesis of tri- and tetracyclic condensed quinoxalin-2-ones fused across the C-3 - N-4 bond

We have studied the preparation of some fused quinoxalinones by Stevens rearrangement of a spiro-quinoxaline-derived ammonium ylide or by treatment of N-(2,4-dinitrophenyl)-and N-(2-nitrophenyl)imino acids with different reducing agents. We have reinvestigated and clarified some related processes found in the literature starting from imino acids derivatives. Additional reactions of the fused quinoxalinones, as well as the useful dehydrogenation/decarboxylation of some easily available 1-arylindoline-2-carboxylic acids to the corresponding 1-arylindoles, are also reported. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Tetrahydropyrroloquinoxalines and Tetrahydropyrrolopyridopyrazines: Vascular Smooth Muscle Relaxants and Antihypertensive Agents

A series of tetrahydropyrroloquinoxalines and tetrahydropyrrolopyridopyrazines were synthesized and tested for their ability to relax K+-depolarized aortic smooth muscle and antihypertensive activity.It was shown that compo