215511-57-2

Upstream product

• 3882-50-6 2-amino-3'-nitro-benzophenone 
• 103711-22-4 α-(Isopropylthio)-Nα-(benzyloxycarbonyl)glycine 

Downstream Products

• 215512-06-4 [5-[3-(Imidazolidin-2-ylideneamino)-phenyl]-2-oxo-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215512-00-8 [5-(3-Isocyano-phenyl)-2-oxo-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215512-02-0 C₃₁H₂₇Br₂N₅O₅S 
• 215511-74-3 [5-(3-Nitro-phenyl)-2-oxo-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215512-04-2 [5-[3-(Imidazolidin-2-ylideneamino)-phenyl]-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215511-95-8 [5-(3-Formylamino-phenyl)-2-oxo-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215511-97-0 [5-(3-Isocyano-phenyl)-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215511-87-8 4-[5-(3-Nitro-phenyl)-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-butyric acid ethyl ester 
• 215512-01-9 C₂₉H₂₈Br₂N₄O₅S 
• 215511-71-0 [5-(3-Nitro-phenyl)-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215511-89-0 4-[5-(3-Nitro-phenyl)-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-butyric acid 
• 215511-79-8 [5-(3-Amino-phenyl)-2-oxo-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215511-93-6 [5-(3-Formylamino-phenyl)-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 
• 215511-76-5 [5-(3-Amino-phenyl)-2-oxo-3-(toluene-4-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Design, syntheses, and activity of new 3-[(sulfonylaryl)-amino]-1,4-benzodiazepin-2-one derivatives as α-thrombin inhibitors

Thrombin plays a central role in thrombosis. Because of the medical need for novel antithrombotic drugs, a search for structurally novel thrombin inhibitors was undertaken. in the absence of a crystal structure, a class was designed based on a modeling approach which involved placing the essential functional groups of the thrombin antagonist MD-805 [1] (Argatroban) into the benzodiazepine nucleus. The best superposition was obtained with a 1,4-benzodiazepin-2-one containing a 1,2,3,3-tetrahydro quinalylsulfonyl moiety in the 3-position, a guanidino-phenyl at the 5-position, and N1-substituted with an acetic acid. Synthesis of these molecules provided compounds with an inhibitory activity with K(i) in the range of 40-1000 μM. A report on the crystal structure of thrombin*hirudin(55-65)*MD-805 complex [2] suggested subsequent molecular modeling investigations to rationalize the pharmacological results.