{Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester
CAS No.:215511-57-2
Molecular Formula:C₂₆H₂₅N₃O₆S
Molecular Weight:507.567
Hs Code.:

Synonyms:{Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

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Chemical Property of {Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

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Technology Process of {Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

There total 1 articles about {Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3882-50-6
2-amino-3'-nitro-benzophenone

: 103711-22-4
α-(Isopropylthio)-Nα-(benzyloxycarbonyl)glycine

: 215511-57-2
{Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1) CH₂Cl₂, 0 deg C, 15 min, 2) CH₂Cl₂, reflux, 20 min, r.t., overnight;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 215511-57-2
{Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

: 215511-60-7
{Amino-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

Guidance literature:: With ammonia; mercury dichloride; In tetrahydrofuran; at 0 ℃; for 3h; Yield given;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 215511-57-2
{Isopropylsulfanyl-[2-(3-nitro-benzoyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

: [5-(3-Amino-phenyl)-2-oxo-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NH₃, HgCl₂ / tetrahydrofuran / 3 h / 0 °C

2: 64 percent / NH₄OAc / acetic acid / Ambient temperature

3: 97 percent / 33percent HBr / acetic acid / 1) 0 deg C, 10 min, 2) 25 deg C, 30 min

4: 84 percent / pyridine / 1) 0 deg C, 15 min, 2) reflux, 1.5 h

5: 97 percent / K₂CO₃ / dimethylformamide / 2 h / 25 °C

6: 84 percent / NEt₃, 97percent HCOOH / 5percent Pd/C / acetonitrile / Heating

7: 68 percent / TFA / CHCl₃ / 3 h / Heating

With pyridine; formic acid; ammonium acetate; ammonia; hydrogen bromide; potassium carbonate; triethylamine; trifluoroacetic acid; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; chloroform; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0223-5234(98)80048-2