215530-62-4

Usage

Uses

Due to the limited information available on the specific applications of 6-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic Acid, it is difficult to provide a comprehensive list of its uses. However, based on its chemical structure and the fact that it is a synthetic organic compound, it can be inferred that it may have potential applications in various fields, such as:
Used in Pharmaceutical Industry:
6-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic Acid could be used as an intermediate or building block in the synthesis of pharmaceutical compounds, given its unique triazolopyridazine structure and carboxylic acid group. This may allow for the development of new drugs with novel therapeutic properties.
Used in Chemical Research:
As a synthetic organic compound, 6-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic Acid may be utilized in academic research settings to study its chemical properties, reactivity, and potential interactions with other molecules. This could lead to a better understanding of its potential applications and uses in various chemical processes.
Used in Material Science:
The unique structure of 6-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic Acid may also make it a candidate for use in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity. This could be particularly relevant in fields like catalysis or the development of new polymers.

InChI:InChI=1/C6H3ClN4O2/c7-3-1-2-4-8-5(6(12)13)10-11(4)9-3/h1-2H,(H,12,13)

Upstream product

• 55643-82-8 6-Chloro-2-methyl-s-triazolo<1,5-b>pyridazine 

Downstream Products

• 215530-36-2 [6-[3-[4-(diphenylmethoxy)piperidino]-propylamino][1,2,4]triazolo[1,5-b]pyridazin-2-yl]carboxylic acid 
• 215530-42-0 isopropyl [6-[3-[4-(diphenylmethoxy)-piperidino]propoxy][1,2,4]triazolo[1,5-b]pyridazin-2-yl]carboxylate 
• 215530-43-1 [6-[3-[4-(diphenylmethoxy)piperidino]-propoxy][1,2,4]triazolo[1,5-b]pyridazin-2-yl]carboxylic acid 

Relevant academic research and scientific papers

Condensed pyridazine derivatives, their production and use

A condensed pyridazine derivative which is useful as a pharmaceutical composition for preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria and prurigo.

Synthesis of eosinophil infiltration inhibitors with antihistaminic activity.

A series of [1, 2, 4]triazolo[1, 5-b]pyridazines (5) and imidazo[1, 2-b]pyridazines (6) having cyclic amines was synthesized and evaluated for antihistaminic activity and inhibitory effect on eosinophil infiltration. When a piperidine or a piperazine containing a benzhydryl group and a suitable spacer was incorporated at the 6-position, the fused pyridazines were found to exhibit both antihistaminic activity and an inhibitory effect on eosinophil chemotaxis. Above all, 6a showed potent antihistaminic activity, but little blockade of central H(1) receptors in contrast with its complete blockade of peripheral H(1) receptors as determined by an ex vivo binding assay. Furthermore, 6a inhibited eosinophil infiltration of the skin caused by a topical antigen challenge in sensitized guinea pigs, while an antihistamine terfenadine was not effective. After the pharmacokinetic study, 6a was found to be rapidly hydrolyzed to 6o, which was also orally active. Compound 6o, 2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1, 2-b]pyridazin-2-yl]-2-methylpropionic acid dihydrate (TAK-427), having both antihistaminic and antiinflammatory activity, is currently undergoing clinical trials as a therapeutic agent for atopic dermatitis and allergic rhinitis.

NASAL DROPS CONTAINING FUSED PYRIDAZINE DERIVATIVES

A nose drop containing the compound (I) represented by the formula wherein Ar1 and Ar2 are each an aromatic group, Ar1 and Ar2 optionally form a condensed cyclic group together with the adjacent carbon atom, ring B is a nitrogen-containing heterocycle, X and Y are each a bond, an oxygen atom or S(O)p (p is 0 to 2), NR4 (R4 is H or a lower alkyl group) or a divalent linear lower hydrocarbon group optionally having substituents and containing 1 to 3 heteroatoms, A is N or CR7 (R7 is H, a halogen atom, a hydrocarbon group, an acyl group or a hydroxy group optionally having substituents), R1, R2 and R3 are each H, a halogen atom, a hydrocarbon group, an acyl group or a hydroxy group optionally having substituents, and R8 is H, a hydroxy group optionally substituted by a lower alkyl group or a carboxyl group, provided that the nitrogen-containing heterocycle represented by ring B is not a heterocycle represented by the formula wherein n is 0 - 1, or a salt thereof or a prodrug thereof, exhibits a superior prophylactic or therapeutic effect on allergic rhinitis and the like.

Condensed pyridazine derivatives, their production and use

The present invention provides a compound represented by the formula: wherein Ar1 and Ar2 are independently an aromatic group which may be substituted, and Ar1 and Ar2 may form a condensed cyclic group with an adjacent carbon atom; ring B is a nitrogen-containing heterocycle which may be substituted; X and Y are the same or different and are independently a bond, an oxygen atom, S(O)p (p is an integer of 0 ot 2), NR4 wherein R4 is a hydrogen atom or a lower alkyl group, or a bivalent linear lower hydrocarbon group which may contain 1 to 3 hetero atoms and the bivalent linear lower hydrocarbon group may be substituted; A is a nitrogen atom or CR7 wherein R7 is a hydrogen atom, a halogen atom, a hydrocarbon which may be substituted, an acyl group or a hydroxy group which may be substituted; R1, R2 and R3 are the same or different and are independently a hydrogen atom, a halogen atom, a hydrocarbon group which may be substituted, an acyl group or a hydroxy group which may be substituted; R8 is a hydrogen atom, a hydroxy group which may be substituted by a lower alkyl or a carboxyl group, or a salt thereof, which exhibits excellent anti-histaminic or eosinophil chemotaxis-inhibiting activities and is useful in treatment or prevention of asthma, allergic conjunctivitis, allergic rhinitis, chronic urticaria or atopic dermatitis.