55643-82-8Relevant academic research and scientific papers
Bimetallic copper and zinc-catalyzed oxidative cycloaddition of 3-aminopyridazines and nitriles: A direct synthesis of 1,2,4-triazolo[1,5-: B] pyridazines via C-N and N-N bond-forming process
Mu, Qiu-Chao,Lv, Ji-Yuan,Chen, Mu-Yi,Bai, Xing-Feng,Chen, Jing,Xia, Chun-Gu,Xu, Li-Wen
, p. 37208 - 37213 (2017/08/09)
One-pot formation of the 1,2,4-triazolo[1,5-b]pyridazine nucleus and its derivatives is presented in this manuscript, in which the desired targets are offered easily via cooperative Cu(i) and Zn(ii)-catalyzed tandem C-N addition and subsequent I2/KI-mediated intramolecular oxidative N-N bond formation.
COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
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, (2016/12/07)
The present invention provides compounds of formula (I) wherein A, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
Reactions of N-Heteroarylformamide Oximes and N-Heteroarylacetamide Oximes with N,N-Dimethylformamide Dimethyl Acetal. Synthesis of 2-Methyl-s-triazoloazines and N-Methylcyanoaminoazines
Stanovnik, Branko,Stimac, Anton,Tisler, Miha,Vercek, Bojan
, p. 577 - 583 (2007/10/02)
N-Heteroarylformamide oximes 3 (R = H) were converted with N,N-dimethylformamide dimethyl acetal (DMFDMA) into N-heteroaryl-N-methylcyanoamino compounds 5, as the main products.In some instances N-heteroarylcyanoamino compounds 4, cyanoimino compounds 7, and some other products, such as 9 and 10 were also formed.On the other hand, N-heteroarylacetamide oximes 3 (R = CH3) were cyclized under the same reaction conditions into 2-methyl-s-triazoloazines (6).N-Heteroarylacetamide O-methyl oximes 11 and 12 were prepared from the corresponding acetamidines 2 (R = CH3) and O-methylhydroxylamine.
