215600-09-2

Upstream product

• 17843-01-5 diethyl (ethoxycarbonyl)(difluoromethyl)phosphonate 
• 115878-98-3 (R)-1-(but-3-ene-1-sulfinyl)-4-methyl-benzene 

Downstream Products

• 215600-15-0 {Difluoro-[(2R,3S)-5-oxo-3-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-methyl}-phosphonic acid diethyl ester 
• 215600-12-7 [(2S,3S)-1,1-Difluoro-2-hydroxy-3-((R)-toluene-4-sulfinyl)-hex-5-enyl]-phosphonic acid diethyl ester 
• 215600-11-6 [(2S,3R)-1,1-Difluoro-2-hydroxy-3-((R)-toluene-4-sulfinyl)-hex-5-enyl]-phosphonic acid diethyl ester 
• 215600-10-5 [(2R,3S)-1,1-Difluoro-2-hydroxy-3-((R)-toluene-4-sulfinyl)-hex-5-enyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of 3′-arylsulfonyl-4′-[(diethoxyphosphoryl)difluoromethyl]thymidine analogs

D- and L-Diethoxyphosphoryldifluoromethyl nucleoside analogs 8, bearing a sulfonylic moiety at C-3′ were synthesized following the building block approach to chiral fluorinated molecules. The condensation of ethyl 2-(diethoxyphosphoryl)2,2-difluoroacetate (2) and 4-(4-methylphenylsulfinyl)but-l-ene (3) followed by reduction of the thus formed ketones 4 to alcohols 5 and oxidative cyclization to the furanose derivatives 6 were the key steps of the synthetic sequence.