215600-15-0

Basic information

• Product Name: {Difluoro-[(2R,3S)-5-oxo-3-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-methyl}-phosphonic acid diethyl ester
• CAS NO: 215600-15-0
• Molecular Weight: 426.375
• Mol File: 215600-15-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {Difluoro-[(2R,3S)-5-oxo-3-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-methyl}-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {Difluoro-[(2R,3S)-5-oxo-3-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-methyl}-phosphonic acid diethyl ester(215600-15-0)
• EPA Substance Registry System: {Difluoro-[(2R,3S)-5-oxo-3-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-methyl}-phosphonic acid diethyl ester(215600-15-0)

Safety Data

• Hazardous Substances Data: 215600-15-0(Hazardous Substances Data)

Upstream product

• 215600-10-5 [(2R,3S)-1,1-Difluoro-2-hydroxy-3-((R)-toluene-4-sulfinyl)-hex-5-enyl]-phosphonic acid diethyl ester 
• 17843-01-5 diethyl (ethoxycarbonyl)(difluoromethyl)phosphonate 
• 115878-98-3 (R)-1-(but-3-ene-1-sulfinyl)-4-methyl-benzene 
• 215600-09-2 [1,1-Difluoro-2-oxo-3-((R)-toluene-4-sulfinyl)-hex-5-enyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Synthesis of 3′-arylsulfonyl-4′-[(diethoxyphosphoryl)difluoromethyl]thymidine analogs

D- and L-Diethoxyphosphoryldifluoromethyl nucleoside analogs 8, bearing a sulfonylic moiety at C-3′ were synthesized following the building block approach to chiral fluorinated molecules. The condensation of ethyl 2-(diethoxyphosphoryl)2,2-difluoroacetate (2) and 4-(4-methylphenylsulfinyl)but-l-ene (3) followed by reduction of the thus formed ketones 4 to alcohols 5 and oxidative cyclization to the furanose derivatives 6 were the key steps of the synthetic sequence.