94127-04-5

Basic information

• Product Name: 8-Chloromethylquinoline
• Synonyms: 8-Chloromethylquinoline
• CAS NO: 94127-04-5
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.6302
• Mol File: 94127-04-5.mol

Chemical Properties

• Boiling Point: 310.579 °C at 760 mmHg
• Flash Point: 170.617 °C
• Appearance: /
• Density: 1.23 g/cm³
• CAS DataBase Reference: 8-Chloromethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloromethylquinoline(94127-04-5)
• EPA Substance Registry System: 8-Chloromethylquinoline(94127-04-5)

Safety Data

• Hazardous Substances Data: 94127-04-5(Hazardous Substances Data)

Upstream product

• 611-32-5 8-methylquinoline 
• 7496-46-0 8-bromomethyl-quinoline 

Downstream Products

• 66819-06-5 [8]quinolyl-acetonitrile 
• 215606-70-5 8-iodomethylquinoline 
• 105212-20-2 8-<(trimethylsilyl)methyl>quinoline 
• 1042625-80-8 3-(Quinolin-8-ylmethoxy)-phenylamine 
• 102650-06-6 N-[3-(Quinolin-8-ylmethoxy)-phenyl]-succinamic acid methyl ester 
• 86-59-9 8-carboxyquinoline 
• 1428964-74-2 C₁₇H₁₅FN₂O₂PS^(1-)*Na⁽¹⁺⁾ 
• 1428964-64-0 C₁₇H₁₆N₂O₂PS^(1-)*Na⁽¹⁺⁾ 
• 1428964-39-9 C₁₈H₁₅F₃N₂O₂PS^(1-)*Na⁽¹⁺⁾ 
• 1428964-43-5 C₂₃H₂₀N₂O₂PS^(1-)*Na⁽¹⁺⁾ 
• 1428964-51-5 C₂₄H₂₂N₂O₃PS₂^(1-)*Na⁽¹⁺⁾ 
• 1428964-60-6 C₂₄H₂₂N₂O₂PS^(1-)*Na⁽¹⁺⁾ 

Relevant articles and documents

Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the?directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

Quinolinoxy phenylsulphonamides

New phenylsulphonamide of the formula in which STR1 R1 represents a pyridyl, quinolyl or isoquinolyl radical which is unsubstituted or substituted by halogen, alkyl, cycloalkyl, alkoxy, cyano, nitro, halogenoalkyl, halogenoalkoxy, alkoxycarbonyl or alkylsulphonyl, R2 represents hydrogen, cyano, nitro, halogen, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy or alkoxycarbonyl, R3 represents an aryl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted by halogen, halogenoalkyl, halogenoalkoxy, alkyl, alkoxy, alkylthio, alkylsulphonyl, cyano, nitro or alkoxycarbonyl, the substituents being identical or different, or represents pentafluorophenyl or represents a straight-chain, branched or cyclic alkyl which is unsubstituted or substituted by halogen, aryl, aryloxy, cyano, alkoxycarbonyl, alkoxy, alkylthio or trifluoromethyl, and X represents an --O--, --A--B-- or --B--A-- group where A denotes --O--, STR2 and B denotes --CH2 -- or STR3 where R1 does not represent a pyridyl radical when x represents an --O-- group, and salts thereof are prepared by reacting appropriate amines with sulphonyl halides. The substituted phenylsulphonamides can be employed as active compounds for inhibiting enzymatic reactions and for inhibiting thrombocyte aggregations.

Main Group Conjugated Organic Anion Chemistry. 3. Application of Magnesium-Anthracene Compounds in the Synthesis of Grignard Reagents

Reaction of magnesium-arene compounds, , 1, and some silylanthracene, and/or tertiary amine analogues, with benzylic and allylic chlorides or bromides, and (Me3Si)3CCl, afford Grignard reagents, RMgX, in modest to high yield for chlorides and negligible to high yield for the bromides, in THF, toluene, and hexane at -10 to 20 deg C.Novel benzylic-type Grignard reagents prepared in high yield include those of 9-(chloromethyl)anthracene, 2-(chloromethyl)pyridine and 8-(chloro(or bromo)methyl)quinoline, and poly-Grignard reagents derived from 1,8-bis(chloromethyl)naphthalene, 2,2'-bis(chloromethyl)-1,1'-binaphthyl, and 1,3,5,-tris(chloro(or bromo)methyl)benzene.Grignard reagent formation occurs via electron-transfer reactions.Aryl and alkyl halides yield mainly products derived from addition of the halide across the 9,10-positions of the anthracenes, via nucleophilic substitution or collapse of a diradical cage 2+, (anthracene)-anion radical, RX-anion radical.>