215655-20-2

Basic information

• Product Name: 1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE
• Synonyms: ART-CHEM-BB B020144;BUTTPARK 33\08-78;1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE;AKOS B020144;1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE, PURISS, 98%;1-(2-Chloro-6-fluorobenzyl)piperazine 97%;1-(2-Chloro-6-fluorobenzyl)piperazine97%;1-(2-CHLORO-6-FLUORO-BENZYL)-PIPERAZINE >98%
• CAS NO: 215655-20-2
• Molecular Formula: C11H14ClFN2
• Molecular Weight: 228.69
• Product Categories: Piperaizine;API intermediates;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Piperazines;PiperazinesHeterocyclic Building Blocks
• Mol File: 215655-20-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 145 °C
• Flash Point: >230 °F
• Appearance: /
• Density: 1.202 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: n20/D 1.5470(lit.)
• PKA: 9.01±0.10(Predicted)
• CAS DataBase Reference: 1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE(215655-20-2)
• EPA Substance Registry System: 1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE(215655-20-2)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38-34-20/21/22
• Safety Statements: 26-36/37/39-24/25-22
• WGK Germany: 3
• Hazardous Substances Data: 215655-20-2(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid or solid

InChI:InChI=1/C11H14ClFN2/c12-10-2-1-3-11(13)9(10)8-15-6-4-14-5-7-15/h1-3,14H,4-8H2

Upstream product

• 110-85-0 piperazine 
• 55117-15-2 2-chloro-6 fluorobenzyl chloride 

Downstream Products

• 1383940-83-7 C₂₁H₂₃ClF₄N₂O₂ 
• 1383940-67-7 C₂₁H₂₃ClF₄N₂O₂ 
• 1383940-50-8 C₂₀H₂₃ClF₂N₂O₂ 
• 1383940-35-9 C₂₀H₂₃ClF₂N₂O₂ 
• 1383940-01-9 C₂₀H₂₃Cl₂FN₂O₂ 

Relevant articles and documents

PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS

The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Design and Synthesis of Novel Insecticides Based on the Serotonergic Ligand 1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine(PAPP)

1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) is a 5-HT1A agonist and was reported to display high affinity for serotonin (5-HT) receptor from the parasitic nematode Haemonchus contortus. The present investigation explored the possibility of using PAPP as a lead compound of new insecticides with novel mode of action. On the basis of the PAPP scaffold, a series of 1-arylmethyl-4-[(trifluoromethyl)pyridin-2-yl]piperazine derivatives were designed, synthesized, and evaluated for biological activities against the armyworm Pseudaletia separata (Walker). Bioassays showed that most of the target compounds displayed certain growth-inhibiting activities or larvicidal activities against armyworm. The quantitative structure-activity relationship (QSAR) for growth-inhibiting activities was also analyzed and established.