215718-94-8

Upstream product

• 85591-93-1 3-bromo-4-hydroxymethyl-2,2,5,5-tetramethyl-Δ³-pyrrolin-1-oxyl 
• 98-80-6 phenylboronic acid 
• 215718-79-9 2,5,5-Trimethyl-1-oxy-4-phenyl-5H-pyrrole-3-carboxylic acid ethyl ester 
• 215718-70-0 2,5,5-Trimethyl-1-oxy-4-phenyl-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester 
• 15802-62-7 (Z)-ethyl 2-benzylidenacetoacetate 
• 215718-87-9 C₁₇H₂₂NO₃ 

Downstream Products

• 215719-02-1 C₁₅H₁₉INO 

Relevant academic research and scientific papers

Palladium-catalyzed coupling reactions of paramagnetic vinyl halides

Suzuki, Heck and Sonogishira coupling reactions of paramagnetic vinyl bromides 1-6 gave monofunctional (7a,b), homobifunctional (8a,b, 24), and heterobifunctional pyrroline nitroxides (9-19, 31) under mild conditions in a one-step reaction. From these com

Synthesis of 3,4-disubstituted 2,5-dihydropyrrol-1-yloxyl spin label reagents

4-Alkyl(or aryl)-3-ethoxycarbonyl-2,5-dihydro-1H-pyrrol-1-yloxyl radicals 5a-g were prepared in a multistep reaction via base-catalyzed conjugate addition of 2-nitropropane to β-aryl(or -alkyl)-α, β- unsaturated-α-ethoxycarbonyl ketones to give γ-nitro ketones, followed by a cyclization to 3,4-dihydro-2H-pyrrole 1-oxides, dehydrobromination to 2H- pyrrole 1-oxides and then Grignard reaction. The esters 5a-g are versatile synthons for obtaining highly SH-specific allylic iodide 7a,c-g and methylsulfonylthiomethyl 8a-g spin label reagents.