215725-53-4Relevant academic research and scientific papers
METHODS FOR PREVENTING AND/OR TREATING LYSOSOMAL STORAGE DISORDERS
-
, (2016/01/11)
The present invention provides methods for preventing and/or treating lysosomal storage disorders using 5-(fluoromethyl)piperidine-3,4-diol, 5-(chloromethyl)piperidine-3,4-diol, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, or any combination of two or more thereof. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.
Azasugar derivatives, heparanase inhibitors, method for preparing same, compositions containing same, use thereof
-
Page/Page column 10, (2010/11/29)
The invention concerns heparanase inhibiting compounds of general formula (I) wherein R represents a hydrogen atom, an hydroxyl radical, a —OSO3? radical, a —O—(C1-C5)alkyl radical or an —O— aralkyl radical; Z r
Iminosugars: Potential inhibitors of liver glycogen phosphorylase
Jakobsen, Palle,Lundbeck, Jane M,Kristiansen, Marit,Breinholt, Jens,Demuth, Helle,Pawlas, Jan,Torres Candela, Maria P,Andersen, Birgitte,Westergaard, Niels,Lundgren, Karsten,Asano, Naoki
, p. 733 - 744 (2007/10/03)
The first synthesis of the single isomers 3R, 4R, 5R); 3S,4S,5S); 3R,4R,5S) and 3S,4S, 5R) of 5-hydroxymethyl-piperidine-3,4-diol from Arecolin is reported, including the synthesis of a series of N-substituted derivatives of the 3R,4R,5R)-isomer Isofagomi
Heterocyclic compounds
-
, (2008/06/13)
Novel piperidine compounds are provided, and those compounds are useful in the treatment and/or prevention of diabetes, and especially non-insulin dependent diabetes (NIDDM or type 2 diabetes) including overnight or meal treatment and treatment or prevention of longterm complications, such as retinopathy, neuropathy, nephropathy, and micro- and macroangiopathy; treatment of hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis or myocardial ischemia.
