215739-05-2

Upstream product

• 25909-68-6 [¹³C]-potassium cyanide 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 55815-72-0 [¹³C₁]-4-methoxyphenyl acetic acid 
• 215653-77-3 4-methoxybenzyl-2',4'-dihydroxyphenyl [13C]ketone 
• 215653-78-4 4'-methoxybenzyl-7-hydroxy-[4-13C]isoflavone 
• 388582-25-0 (4-methoxyphenyl) ([5-13C]tetrazol-5-yl)methyl phenyl ketone 
• 388582-21-6 ([13C]cyano)(4-methoxyphenyl)methyl phenyl ketone 

Relevant academic research and scientific papers

Synthesis of [4-13C]-isoflavonoid phytoestrogens

Efficient syntheses are described for 13C-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs 13C-labelled cyanide as the source of the label to produce the isoflavones with a single 13C atom at the C-4 position. (C) 2000 Elsevier Science Ltd.

SYNTHESIS OF 13C-LABELLED ESTROGEN ANALOGUES

There is provided a method of producing novel 13C-labelled estrogen analogues. The method preferably proceeds via an intermediate A or B or which is a mixture of (A) or (B): wherein a13C atom is located at one or more of positions 1, 2, 3 or 4 and wherein R is an optionally substituted alkane, alkene, alkyne or aryl group. Preferably R is -CH2Ph. An alternative preferred intermediate compound is 13C-resorcinol.

Synthesis of 13C labelled daidzein and formononetin.

Efficient methods are described for the synthesis of daidzein and formononetin labelled with a single 13C atom at the 4-position, to prepare material for metabolic studies.