2158-59-0

Basic information

• Product Name: 2-Cyclohexen-1-one, 4-(1-methylethyl)-, (4R)-
• CAS NO: 2158-59-0
• Molecular Formula: C9H14O
• Molecular Weight: 138.21
• Mol File: 2158-59-0.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: 2-Cyclohexen-1-one, 4-(1-methylethyl)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclohexen-1-one, 4-(1-methylethyl)-, (4R)-(2158-59-0)
• EPA Substance Registry System: 2-Cyclohexen-1-one, 4-(1-methylethyl)-, (4R)-(2158-59-0)

Safety Data

• Hazardous Substances Data: 2158-59-0(Hazardous Substances Data)

Upstream product

• 76640-26-1 (R)-5-Isopropyl-2-methoxy-cyclohexa-1,3-diene 
• 6153-17-9 (-)-β-phellandrene 
• 24903-94-4 7-methyl-1,6-octadiene-3-one 
• 77982-63-9 nopinone 
• 24903-95-5 (+)-nopinone 
• 513-20-2 sabinaketone 
• 7664-93-9 sulfuric acid 
• 5259-66-5 isopropyl-4 cyclohexene-3 one-1 
• 97857-20-0 menth-2-ene-1,7-diol 
• 108-75-8 2,4,6-trimethyl-pyridine 
• 177698-19-0 Beta-pinene 
• 24903-95-5 nopinone 
• 190718-78-6 ((4S)-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-1-yl)methanol 
• 536-59-4 (-)-perillyl alcohol 

Downstream Products

• 99-83-2 p-mentha-1,5-diene 
• 619-62-5 1-methyl-4-(1-methylethyl)-2-cyclohexen-1-ol 
• 5432-85-9 4-isopropyl-cyclohexanone 
• 215456-39-6 (-)-cryptone oxime 
• 2158-59-0 cryptone 
• 79120-25-5 (R)-(-)-cryptone semicarbazone 
• 4581-63-9 (+/-)-4-isopropyl-cyclohex-2-enone semicarbazone 
• 2153-64-2 (R)-4-isopropyl-cyclohex-2-enone-(2,4-dinitro-phenylhydrazone) 
• 2153-64-2 (+/-)-4-isopropyl-cyclohex-2-enone-(2,4-dinitro-phenylhydrazone); (+/-)-cryptone-(2,4-dinitro-phenylhydrazone) 
• 119216-30-7 (3R,4S)-4-Isopropyl-3-(5-trimethylsilanyl-furan-2-yl)-cyclohexanone 
• 119987-64-3 4-Isopropyl-3-vinyl-cyclohexanone 
• 119987-63-2 3-Butyl-4-isopropyl-cyclohexanone 
• 555-10-2 beta-phellandrene 
• 39725-34-3 4-hydroxy-4-isopropyl-2-cyclohexenone 

Relevant articles and documents

Total syntheses of (+)-adunctins C and D: Assignment of their absolute configurations

The first total synthesis of (+)-adunctin C (ent-1) and (+)-adunctin D (2), two monoterpene-substitued dihydrochalcones isolated from Piper aduncum (Piperaceae), was achieved. A regioselective oxidative [3 + 2] cycloaddition of acylphloroglucinol with (-)-β-phellandrene was developed to construct their unique spirobenzofuran skeleton. The absolute configurations of natural adunctins 1 and 2 were thus assigned through these endeavors. This journal is

Synthetic method of stealthy ketone (by machine translation)

The method disclosed by the invention is characterized in that the, method for synthesizing: the octrexone by the step of reacting synthetic enamine with tetrahydropyrrole and isovaleraldehyde; under 2 - 6h a basic condition of water to 2 - obtain a latent ketone crude; product comprises the following 2 - steps of: refluxing under, the alkaline condition, of water; and, distilling off the solvent, under reduced pressure, to obtain a latent ketone crude product . (by machine translation)

Antimalarial Properties of Simplified Kalihinol Analogues

Several kalihinol natural products, members of the broader isocyanoterpene family of antimalarial agents, are potent inhibitors of Plasmodium falciparum, the agent of the most severe form of human malaria. Our previous total synthesis of kalihinol B provided a blueprint to generate many analogues within this family, some as complex as the natural product and some much simplified and easier to access. Each analogue was tested for blood-stage antimalarial activity using both drug-sensitive and -resistant P. falciparum strains. Many considerably simpler analogues of the kalihinols retained potent activity, as did a compound with a different decalin scaffold made in only three steps from sclareolide. Finally, one representative compound showed reasonable stability toward microsomal metabolism, suggesting that the isonitrile functional group that is critical for activity is not an inherent liability in these compounds.