215812-90-1

Upstream product

• 68207-79-4 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-2-methylsulfanyl-3,5-dihydro-imidazol-4-one 
• 74-88-4 methyl iodide 
• 64958-41-4 5-(2-chlorobenzylidene)-2-thiohydantoin 
• 215812-88-7 2-thioxo-5-(2-chlorophenylmethylidene)-4-imidazolidinone 

Relevant academic research and scientific papers

The synthesis of 2-alkylthio-3-alkyl-5-arylmethylidene-4H-imidazol-4-ones

2-alkylthio-3-alkyl-5-arylmethylidene-4H-imidazol-4-ones were synthesized by the S-alkylation and N-alkylation of 2-thioxo-5-arylmethylidene-4- imidazolidinones, which were obtained via a tandem aza-Wittig reaction of vinyliminophosphoranes, carbon disulf

Synthesis, spectral and antimicrobial properties of 5-chloroarylidene aromatic derivatives of imidazoline-4-one

The synthesis of new chloro-benzylidene substituted derivatives of hydantoin and their antimicrobial activity is reported. The structure-activity relationships showed that the antibacterial effect of investigated compounds depends on the distance of the phenyl ring from the amine residue and the kind of substitutes on the phenyl ring. In the investigated group of derivatives, 5-(2-chlorobenzylidene)-2-(4-fluorobenzylamine)-imidazoline-4-one and 5-(2- chlorobenzylidene)-2-(2-phenylethylamine)-imidazoline-4-one showed the best antibacterial activity against Moraxella catarrhalis.