68207-79-4Relevant academic research and scientific papers
Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2
Szymanska, Ewa,Kie-Kononowicz, Katarzyna,Bialecka, Anna,Kasprowicz, Andrzej
, p. 39 - 44 (2007/10/03)
Various 5-chloroarylidene-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated for their activity in vitro against Mycobacterium tuberculosis and other type strains of bacteria and fungi. 2-Chloro- and 2,4-dichlorobenzylidene substituted hydantoins exhibited antimycobacterial effect. The most potent compounds 3i, 3j, 3o, 3q and 3s were classified for further tests. The antimitotic effect of the investigated hydantoins was also examined.
Glycine derivatives of imidazolones as potential ligands of glycine binding site of NMDA receptors. Part 1
Kiec-Kononowicz, Katarzyna,Karolak-Wojciechowska, Janina,Handzlik, Jadwiga
, p. 381 - 388 (2007/10/03)
The series of glycine derivatives of diphenyl or (un)substituted arylidene imidazolones was designed and obtained as potential ligands of the glycine binding site of NMDA receptors. The compounds were evaluated in vitro for their affinity to the glycine b
Synthesis, spectral and antimicrobial properties of 5-chloroarylidene aromatic derivatives of imidazoline-4-one
Kiec-Kononowicz, Katarzyna,Szymanska,Motyl,Holzer,Bialecka,Kasprowicz
, p. 680 - 684 (2007/10/03)
The synthesis of new chloro-benzylidene substituted derivatives of hydantoin and their antimicrobial activity is reported. The structure-activity relationships showed that the antibacterial effect of investigated compounds depends on the distance of the phenyl ring from the amine residue and the kind of substitutes on the phenyl ring. In the investigated group of derivatives, 5-(2-chlorobenzylidene)-2-(4-fluorobenzylamine)-imidazoline-4-one and 5-(2- chlorobenzylidene)-2-(2-phenylethylamine)-imidazoline-4-one showed the best antibacterial activity against Moraxella catarrhalis.
