215929-28-5

Upstream product

• 53389-98-3 2-(benzyloxy)-5-methylsalicylaldehyde 
• 100-39-0 benzyl bromide 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 98-80-6 phenylboronic acid 
• 6627-55-0 2-bromo-p-cresol 
• 155835-37-3 (4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone 
• 2830-53-7 1-(benzyloxy)-2-bromo-4-methylbenzene 
• 215929-27-4 (R)-3-[(R)-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionyl]-4-phenyloxazolidin-2-one 

Downstream Products

• 1191280-47-3 (R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-di(isopropyl-d7)-3-phenylpropan-1-amine 
• 1191280-46-2 (R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-di(isopropyl-d7)-3-phenylpropanamide 
• 1191280-48-4 (R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-methylphenol L-tartrate 
• 848768-06-9 (R)-3-[2-(benzyloxy)-5-methylphenyl]-N,N-diisopropyl-3-phenylpropan-1-amine 
• 1191280-45-1 (R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropanoyl chloride 
• 124937-51-5 (R)-(+)-tolterodine 
• 215929-29-6 (R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide 

Relevant academic research and scientific papers

Rh-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to 3-Arylpropenoates: Enantioselective Synthesis of (R)-Tolterodine

A highly enantioselective conjugate addition of arylboronic acids to 3-arylpropenoates is presented. The rhodium complexes obtained from deoxycholic acid derived binaphthyl phosphites showed good activity as well as very high enantioselectivity (ee up to 99 %) in the conjugate addition to different ethyl-3-arylpropenoates, allowing to obtain useful chiral building blocks for the synthesis of active pharmaceutical ingredients. The method was applied to the enantioselective synthesis of the antimuscarinic drug (R)-tolterodine.

DERIVATIVES OF 3-(2-HYDROXY-5-METHYPHENYL)-N,N-DIISOPROPYL-3-PHENYLPROPYLAMINE AND METHODS OF USE THEREOF

This invention relates to novel derivatives of tolterodine, 5-hydroxymethyl tolterodine, fesoterodine and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such comp