215932-97-1Relevant academic research and scientific papers
Synthesis and reaction of 2-mercapto-3-arylpropanoic acids
Pokhodylo, Nazariy T.,Matiychuk, Vasyl S.,Obushak, Mykola D.
experimental part, p. 850 - 858 (2012/08/07)
Two synthetic pathways for the preparation of 2-mercapto-3-arylpropanoic acids were developed. First, by the reaction of arenediazonium bromides with acrylic esters in the presence of CuBr, alkyl (2-bromo-3-aryl)propanoates were formed. Their cyclization with thiourea produced 5-(R-benzyl)-2-imino-4- thiazolidinones, which yielded 3-aryl-2-mercaptopropanoic acids by alkaline hydrolysis. Second, direct Meerwein arylation of acrylates in the presence of S-nucleophile (NaSH) allowed isolation of 3-phenyl-2-mercaptopropanoic acid in 8% yield. Such acids were used for cyclization with cyanoguanidine and phenyl isothiocyanate yielding 1-[5-(R-benzyl)-4-oxo-1,3-thiazolidin-2-ylidene] guanidines and new 5-(R-benzyl)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one (rhodanine) derivatives correspondingly. Copyright Taylor and Francis Group, LLC 2012.
Synthesis of heterocycles on the basis of arylation products of unsaturated compounds. 11.1 5-R-benzyl-2-iminoselenazolidin-4-ones from ethyl 3-aryl-2-bromopropanoates
Obushak, Mykola D.,Matiychuk, Vasyl S.,Tsyalkovsky, Volodymyr M.,Voloshchuk, Roman M.
, p. 107 - 113 (2007/10/03)
Ethyl 3-aryl-2-bromopropanoates 2a-p were prepared by reaction of ethyl acrylate with arenediazonium bromides 1a-p in the presence of CuBr (Meerwein arylation). These compounds react with selenourea to form 5-R-benzyl-2- iminoselenazolidin-4-ones 4a-p. Compounds 4a-p hydrolyze into the corresponding selenazolidin-2,4-diones.
Synthesis of Heterocycles Based of the Products of Anionarylation of Unsaturated Compounds. II. * Method of Preparation of 2,5-Disubstituted 4-Thiazolidones
Obushak,Matiichuk,Ganushchak
, p. 239 - 244 (2007/10/03)
The products of haloarylation of acrylates by aryldiazonium salts (Meerwein reaction) react with thiourea and thiosemicarbazones forming thiazolidone cycle. The reaction is a convenient synthesis method of 5-benzylsubstituted 2-imino-4-thiazolidones and 2
