215959-64-1

Upstream product

• 109428-30-0 1,5:2,3-anhydro-4,6-O-benzylidene-D-allitol 
• 181711-37-5 1-((4aR,7R,8S,8aS)-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-1H-pyrimidine-2,4-dione 

Downstream Products

• 215959-65-2 1,5-anhydro-3-O-benzoyl-2-deoxy-2-(uracil-1-yl)-D-altro-hexitol 
• 215959-66-3 1,5-anhydro-3-O-benzoyl-6-O-monomethoxytrityl-2-deoxy-2-(uracil-1-yl)-D-altro-hexitol 

Relevant academic research and scientific papers

1,5-Anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA

As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blocks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (d(h)U)13/(dA)13 duplex.