216005-97-9

Upstream product

• 216005-96-8 {2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-[1,3]dioxolan-2-ylethynyl-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester 
• 216005-90-2 {2-[(1S,2R)-1-(3,4-Dimethoxy-phenyl)-2-hydroxy-cyclohexyl]-ethyl}-methyl-carbamic acid methyl ester 
• 10160-87-9 Propiolaldehyde diethyl acetal 
• 216005-93-5 {2-[(R)-1-(3,4-Dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid methyl ester 
• 189363-85-7 2-(3,4-dimethoxyphenyl)-2-cyclohexen-1-ol 
• 216005-89-9 (1R,2S)-2-(3,4-Dimethoxy-phenyl)-2-(2-methylamino-ethyl)-cyclohexanol 
• 216005-86-6 (3aS,7aS)-3a-(3,4-Dimethoxy-phenyl)-hexahydro-benzofuran-2-one 
• 216005-85-5 (3aS,7aS)-3a-(3,4-Dimethoxy-phenyl)-2-ethoxy-octahydro-benzofuran 
• 216005-84-4 4-[(S)-6-(2-Bromo-1-ethoxy-ethoxy)-cyclohex-1-enyl]-1,2-dimethoxy-benzene 
• 216005-88-8 2-[(S)-1-(3,4-Dimethoxy-phenyl)-2-oxo-cyclohexyl]-N-methyl-acetamide 
• 216005-87-7 2-[(1S,2S)-1-(3,4-Dimethoxy-phenyl)-2-hydroxy-cyclohexyl]-N-methyl-acetamide 
• 216006-02-9 2,2-Dimethyl-propionic acid (S)-2-(3,4-dimethoxy-phenyl)-cyclohex-2-enyl ester 
• 216005-83-3 2,2-Dimethyl-propionic acid (1S,2S)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-cyclohexyl ester 
• 216005-92-4 {2-[(R)-1-(3,4-Dimethoxy-phenyl)-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid methyl ester 

Downstream Products

• 216005-98-0 {2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-amine 
• 35135-35-4 3a-(3,4-dimethoxy-phenyl)-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline 

Relevant academic research and scientific papers

Asymmetric synthesis of sceletium alkaloids: (-)-Mesembrine, (+)- sceletium a-4, (+)-tortuosamine and (+)-N-formyltortuosamine

Three procedures for the transformation of achiral 1-(3,4- dimethoxyphenyl)cyclohexene into enantiomerically pure 2-(3,4- dimethoxyphenyl)cyclohex-2-en-1-o1 have been established at first. Utilizing the (-)-cyclohexenol thus obtained, the four titled Sceletium alkaloids have been synthesized in the natural enantiomeric forms.