21601-26-3

Upstream product

• 17422-74-1 3-Formylchromone 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 115848-54-9 C₁₆H₁₁BrN₂O₂ 
• 61466-44-2 4-(2-hydroxybenzoyl)-1-phenylpyrazole 
• 115848-59-4 dimethyl 3-(4-oxo-4H-chromen-3-yl)-1-phenyl-1H-pyrazole-4,5-dicarboxylate 
• 115848-58-3 3-(1,4-Diphenyl-4,5-dihydro-1H-pyrazol-3-yl)-chromen-4-one 
• 115848-56-1 3-(4-Acetyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-chromen-4-one 
• 115848-57-2 3-(4-Oxo-4H-chromen-3-yl)-1-phenyl-4,5-dihydro-1H-pyrazole-4-carbonitrile 
• 115848-55-0 3-(4-Bromomethyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-chromen-4-one 

Relevant academic research and scientific papers

Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

Synthesis and evaluation of potential pharmacophores derived from 4-oxo-4H-1-benzopyran-3-carboxaldehyde

The preparation of hydrazone derivatives of 4-oxo-4H-1-benzopyran-3-carboxaldehyde (2a-c, 4a-c, 5, 6a,b), 3-aryl-1-(benzopyran-4-one-3-yl)-propen-3-one (8a-c), ethyl 2-cyano-3-(benzopyran-4-one-3-yl)acrylate (10) and thioacetal derivatives of 4-oxo-4H-1-b

STUDIES IN CHROMONE DERIVATIVES: CYCLOADDITION REACTIONS OF 4-OXO-4H-1-BENZOPYRAN-3-CARBOXALDEHYDE IMINES WITH BENZONITRILE OXIDE AND NITRILIMINE OF 4-OXO-4H-1-BENZOPYRAN-3-CARBOXALDEHYDE WITH ALKENES

The chromone imines 1 and benzonitrile oxide reacted regiospecifically to yield Δ2-1,2,4 oxadiazolinyl chromones 2 in good yields.Also the preparation of a novel dipole 6 derived from 3-formylchromone and its cycloaddition reactions with a vari