216012-32-7Relevant academic research and scientific papers
Tricyclic pyridones as functionally selective human GABA Aα2/3 receptor-ion channel ligands
Crawforth, James,Atack, John R.,Cook, Susan M.,Gibson, Karl R.,Nadin, Alan,Owens, Andrew P.,Pike, Andrew,Rowley, Michael,Smith, Alison J.,Sohal, Bindi,Sternfeld, Francine,Wafford, Keith,Street, Leslie J.
, p. 1679 - 1682 (2007/10/03)
A series of tricyclic pyridones has been evaluated as benzodiazepine site ligands with functional selectivity for the α3 over the α1 containing subtype of the human GABAA receptor ion channel. This investigation led to the
Synthesis of tricyclic pyridones by radical cyclization
Nadin, Alan,Harrison, Timothy
, p. 4073 - 4076 (2007/10/03)
A general and novel route for the synthesis of tricyclic pyridones by 5- , 6- and 7-exo-trig radical cyclization is described. The use of Pd-catalyzed cross-coupling reactions to introduce functionality at the 5-position of a pyridone is also presented.
