216012-90-7Relevant academic research and scientific papers
Tricyclic pyridones as functionally selective human GABA Aα2/3 receptor-ion channel ligands
Crawforth, James,Atack, John R.,Cook, Susan M.,Gibson, Karl R.,Nadin, Alan,Owens, Andrew P.,Pike, Andrew,Rowley, Michael,Smith, Alison J.,Sohal, Bindi,Sternfeld, Francine,Wafford, Keith,Street, Leslie J.
, p. 1679 - 1682 (2007/10/03)
A series of tricyclic pyridones has been evaluated as benzodiazepine site ligands with functional selectivity for the α3 over the α1 containing subtype of the human GABAA receptor ion channel. This investigation led to the
Tricyclic pyridone analogues as GABA-A receptor ligands
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, (2008/06/13)
PCT No. PCT/GB98/01167 Sec. 371 Date Sep. 27, 1999 Sec. 102(e) Date Sep. 27, 1999 PCT Filed Apr. 22, 1998 PCT Pub. No. WO98/50384 PCT Pub. Date Nov. 12, 1998Tricyclic pyridin-2-one analogues which are ligands for GABAA receptors, are useful in the therapy
Synthesis of tricyclic pyridones by radical cyclization
Nadin, Alan,Harrison, Timothy
, p. 4073 - 4076 (2007/10/03)
A general and novel route for the synthesis of tricyclic pyridones by 5- , 6- and 7-exo-trig radical cyclization is described. The use of Pd-catalyzed cross-coupling reactions to introduce functionality at the 5-position of a pyridone is also presented.
