216064-18-5Relevant academic research and scientific papers
[Cu(NHC)]-Catalyzed C-H Allylation and Alkenylation of both Electron-Deficient and Electron-Rich (Hetero)arenes with Allyl Halides
Xie, Weilong,Chang, Sukbok
, p. 1876 - 1880 (2016)
New reactivity of a [Cu(NHC)] (NHC=N-heterocyclic carbene) catalyst is disclosed for the efficient C-H allylation of polyfluoroarenes using allyl halides in benzene at room temperature. The same catalyst system also promotes an isomerization-induced alkenylation of initially the generated allyl arenes when the reaction is run in tetrahydrofuran. Significantly, not only electron-deficient but also electron-rich (hetero)arenes undergo this double-bond migration process, thus leading to alkenylated products. The present system features mild reaction conditions, broad scope with respect to the arene substrates and allyl halide reactants, good functional-group tolerance, and high stereoselectivity.
Ozonolysis of Alkenes and Studies of the Reactions of Polyfunctional Compounds. LVIII. Ozonolysis of 2,6-Difluoro-β,β-Dimethylstyrene as an Effective Way to 2,6-Difluorobenzamide and Synthesis of New Analogs of Difluorobenzurone
Odinokov,Ishmuratov,Kukovinets,Harisov,Lozhkina,Mustafin,Abdrahmanov,Tolstikov
, p. 202 - 204 (2007/10/03)
Ozonolysis of 2,6-difluoro-β,β-dimethylstyrene, formed by isomerization of the product of alkylation of sodium derivative of m-difluorobenzene with methallyl chloride, yields 2,6-difluorobenzamide, transformation of which to 2,6-difluorobenzoyl isocyanate and the reaction of the latter with corresponding arylamines leads to new effective analogs of difluorobenzurone.
