18063-03-1

Basic information

• Product Name: 2,6-Difluorobenzamide
• Synonyms: Fluorine benzaMide 2, 6-2;2,6-difluoro-benzamid;2,6-DIFLUOROBENZAMIDE;2，6-difluorobenzaminde;2,6-difluorobenzoic acid amide;2,6-Difluorobenzamide97%;2,6-Difluorbenzamid;2,6-Difluorobenzoylamide
• CAS NO: 18063-03-1
• Molecular Formula: C₇H₅F₂NO
• Molecular Weight: 157.12
• EINECS: 241-972-8
• Product Categories: Organic Building Blocks;Aryl Fluorinated Building Blocks;Building Blocks;C7;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;intermediate;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Amides;Carbonyl Compounds
• Mol File: 18063-03-1.mol
• Article Data: 24

Chemical Properties

• Melting Point: 145-148 °C(lit.)
• Boiling Point: 51-52C/15Tor
• Flash Point: 67.3 °C
• Appearance: white powder
• Density: 1,199g/cm
• Vapor Pressure: 0.622mmHg at 25°C
• Refractive Index: 1,508
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: ethanol: soluble5%, clear to turbid, colorless to light yellow
• PKA: 14.54±0.50(Predicted)
• BRN: 2047480
• CAS DataBase Reference: 2,6-Difluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzamide(18063-03-1)
• EPA Substance Registry System: 2,6-Difluorobenzamide(18063-03-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20
• Safety Statements: 26-37/39-36/37
• WGK Germany: 1
• RTECS: CV4355050
• HazardClass: IRRITANT
• Hazardous Substances Data: 18063-03-1(Hazardous Substances Data)

Usage

Description

2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.

Chemical Properties

white to yellowish powder

Uses

2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates.

InChI:InChI=1/C7H5F2NO/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H2,10,11)

Upstream product

• 18063-02-0 2,6-difluorobenzoylchloride 
• 1897-52-5 2,6 difluorobenzonitrile 
• 19064-16-5 2,6-difluoro-benzaldehyde oxime 
• 385-00-2 2,6-difluorobenzoic acid 
• 372-18-9 1,3-Difluorobenzene 
• 135133-56-1 2,6-Difluoro-β,β-dimethylstyrene 
• 216064-18-5 1-(2-Methyl-2-propen-1-yl)-2,6-difluorobenzene 
• 104-12-1 p-chlorphenylisocyanate 
• 79-34-5 1,1,2,2-tetrachloroethane 
• 75-52-5 nitromethane 
• 437-81-0 2,6-difluorobenzaldehyde 
• 118-69-4 2,6-dichlorotoluene 
• 81-19-6 2,6-dichlorobenzalchloride 
• 1194-65-6 2,6-dichloro-benzonitrile 

Downstream Products

• 936482-19-8 2,6-difluoro-N-((Z)-1-methyl-3-oxobut-1-enyl)benzamide 
• 35367-38-5 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea 
• 132506-87-7 N-2,6-difluorobenzoyl-O-methylcarbamate 
• 53981-23-0 2-amino-3-fluorophenol 
• 156778-34-6 N-(2-chloro-1-methoxyethyl)-2,6-difluorobenzamide 
• 1187056-38-7 ethyl 2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylate 
• 1017452-64-0 2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid 
• 1513864-33-9 C₁₂H₁₃F₂NO₂ 
• 71422-67-8 chlorfluazuron 

Relevant articles and documents

SYNTHESIS OF VARIOUS AROMATIC AMIDE DERIVATIVES USING NITRILE HYDRATASE OF RHODOCOCCUS RHODOCHOROUS J1

Nitrile hydratase, that is produced abundantly in cells of Rhodococcus rhodochorous J1, catalyses the conversion of various aromatic nitrile derivatives to the corresponding amides.Using Rh. rhodochorous J1 resting cells, the conditions for the production of benzamide, 2,6-difluorobenzamide, indolacetamide, thiophenecarboxamide and furanecarboxamide were optimized.Under the determined conditions, 489 g of benzamide, 306 g of 2,6-difluorobenzamide, 1045 g of 3-indoleacetamide, 210 g of 2-thiophenecarboxamide and 522 g of 2-furanecarboxamide were produced, with 100percent molar conversion, from the corresponding nitriles, per litre of reaction mixture.

Design, synthesis, and bioactivities of novel pyridazinone derivatives containing 2-phenylthiazole or oxazole skeletons

A series of novel pyridazinone derivatives were designed and synthesized by replacing 4-(tert-butyl)phenyl moiety of pyridaben with 2-phenylthiazole or oxazole fragments via activity substructure connecting approach. The structures of all target compounds were characterized through NMR, MS, and elemental analysis. Bioassay results exhibit that most compounds showed potent bioactivities against Aphis fabae, Tetranychus urticae, Erysiphe graminis, and/or Puccinia polysora. Among the newly synthesized compounds, 2-(tert-butyl)-4-chloro-5-(((2-phenylthiazol-4-yl)methyl)thio)pyridazin-3(2H)-one (12b) displays remarkable insecticidal activity against A fabae. Its LC50 value (2.73 mg/L) is better than that of pyridaben (5.46 mg/L), although inferior to that of imidacloprid (0.51 mg/L). In addition to its extraordinary insecticidal activity, compound 12b also exerts 96.9% fungicidal activities against P polysora at 500 mg/L in vivo, significantly superior to that of pyridaben (50.0%), while slightly lower than that of tebuconazole (100%). This article discusses the synthesis, bioassay results, and structure-activity relationship of this series of novel pyridazinone derivatives.

Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: Synthesis of primary amides

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.