216066-95-4Relevant academic research and scientific papers
Medicine composition for treating heart failure and preparation method and use thereof
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Paragraph 0018; 0020; 0029; 0030; 0031, (2018/09/26)
The invention discloses a medical composition for treating heart failure. According to the medical composition, the load capacity of cardiac muscle cells can be reduced, myocardium oxygen supply is increased, and besides, the myocardial oxygen consumption is reduced. The medical composition achieves the protective effect on cardiac muscle cells. The medical composition structurally comprises 25-35mg of effective drug components and carriers which are pharmaceutically and commonly used, and auxiliary addition components. Besides, the medical composition is safe and efficient, and can be taken for a long term by patients suffering from heart failure.
Reaction of 2-Methylthio-1-cyanoethenyltriphenylphosphonium Iodide with Hydrazine and Its Derivatives
Smolii,Panchishin,Van Meerwelt,Mishchenko,Romanenko,Drach
, p. 548 - 554 (2007/10/03)
Accessible phosphonium reagent (E)-CH3SCH=C(CN)PPh+3 readily reacts with hydrazine, aryl-and acylhydrazines, and N,N-dimethylhydrazine, with nucleophilic substitution of the methylthio group followed by cyclization if two labile hydrogen atoms are available. Heating with arylhydrazines gives 5-amino-1-arylpyrazol-4-yltriphenylphosphonium iodides in good yields; their structure was proved by alkaline phosphorylation. At the same time, the initial product of reaction of the phosphonium reagent with hydrazine after heating in acetic acid and addition of sodium perchlorate transforms into 5-amino-3-triphenylphosphoniopyrazolo[1,5-a]pyrimidine perchlorate; its structure was determined by single crystal X-ray diffraction.
