216104-75-5

Upstream product

• 615-43-0 2-iodophenylamine 
• 87486-35-9 1-benzyl-3,5-dichloro-1H-pyrazin-2-one 

Downstream Products

• 216104-83-5 1-Benzyl-5-chloro-3-[2-(3-hydroxy-prop-1-ynyl)-phenylamino]-1H-pyrazin-2-one 
• 216104-82-4 1-benzyl-5-chloro-3-((2-(phenylethynyl)phenyl)amino)pyrazin-2(1H)-one 
• 1380295-00-0 1-benzyl-3-((2-((4-(tert-butyl)phenyl)ethynyl)phenyl)amino)-5-chloropyrazin-2(1H)-one 
• 1380295-01-1 1-benzyl-5-chloro-3-((2-(m-tolylethynyl)phenyl)amino)pyrazin-2(1H)-one 
• 216104-81-3 1-Benzyl-5-chloro-3-(2-trimethylsilanylethynyl-phenylamino)-1H-pyrazin-2-one 
• 216105-09-8 N-(4-benzyl-6-chloro-3-oxo-3,4-dihydro-2-pyrazinyl)-N-(2-iodophenyl)acetamide 
• 216105-06-5 9-acetyl-4-acetoxymethyl-2-benzyl-2,9-dihydro-1H-β-carbolin-1-one 
• 216105-03-2 2-benzyl-3-cyano-4-phenyl-2,9-dihydro-1H-β-carbolin-1-one 
• 216105-11-2 9-Acetyl-2-benzyl-4-phenyl-2,9-dihydro-β-carbolin-1-one 
• 216105-10-1 9-acetyl-2-benzyl-4-trimethylsilyl-2,9-dihydro-1H-β-carbolin-1-one 
• 216104-88-0 1-Benzyl-5-chloro-3-(2-ethynyl-phenylamino)-1H-pyrazin-2-one 
• 216104-96-0 2-benzyl-4-phenyl-2,9-dihydro-1H-β-carbolin-1-one 
• 216104-95-9 2-Benzyl-4-trimethylsilanyl-2,9-dihydro-β-carbolin-1-one 
• 216105-12-3 9-acetyl-2-benzyl-2,9-dihydro-1H-β-carbolin-1-one 

Relevant academic research and scientific papers

Microwave-assisted synthesis of pyrazino[2,1-b]quinazolines and 3-indolyl-2(1H)-pyrazinones employing a chemoselective silver(I)- and gold(I)-catalyzed reaction

Novel microwave-assisted syntheses of pyrazino[2,1-b]quinazolines and 3-indolyl-2(1H)-pyrazinones employing silver(I)- or gold(I)-catalyzed protocols have been elaborated. The scope and limitations of these processes have been investigated. Copyright

Synthesis of α-carbolines and β-carbolinones via intramolecular Diels- Alder reactions of 2(1H)-pyrazinones

2(1H)-Pyrazinones bearing a X-(o-C6H4)-C≡C-R moiety (X=NH, NAc) are shown to undergo an intramolecular cycloaddition-elimination reaction on thermolysis in refluxing bromobenzene yielding α-carbolines or β- carbolinones. The product distribution depends strongly on the substitution pattern of the pyrazinone precursors and the solvent used for thermolysis. A high yield and selective formation of β-carbolinones is possible when heating in tetrahydronaphthalene at reflux. Use of acetic anhydride as solvent facilitated the reaction and made it possible to realise a carbolin(on)e unaccessible by thermolysis in the previously mentioned solvents.