87486-35-9

Basic information

• Product Name: 1-benzyl-3,5-dichloropyrazin-2(1H)-one
• Synonyms: 1-benzyl-3,5-dichloropyrazin-2(1H)-one;1-Benzyl-3,5-dichloro-1H-pyrazin-2-one
• CAS NO: 87486-35-9
• Molecular Formula: C₁₁H₈Cl₂N₂O
• Molecular Weight: 255.10002
• Mol File: 87486-35-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 80 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 361.6±52.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: -6.65±0.70(Predicted)
• CAS DataBase Reference: 1-benzyl-3,5-dichloropyrazin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3,5-dichloropyrazin-2(1H)-one(87486-35-9)
• EPA Substance Registry System: 1-benzyl-3,5-dichloropyrazin-2(1H)-one(87486-35-9)

Safety Data

• Hazardous Substances Data: 87486-35-9(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3,5-dichloropyrazin-2(1H)-one is a chemical compound with the molecular formula C14H11Cl2N2O. It is a pyrazine derivative with a benzyl group and two chlorine atoms attached to the pyrazine ring. 1-benzyl-3,5-dichloropyrazin-2(1H)-one is used in organic synthesis and medicinal chemistry research. It has potential pharmacological properties and has been studied for its antitumor and antiviral activities. It is important to handle this chemical with caution as it may have toxic or harmful effects if not used properly.

Upstream product

• 100-46-9 benzylamine 
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Downstream Products

• 139268-44-3 2-Benzyl-4,6-dichloro-2,5-diaza-bicyclo[2.2.2]oct-5-en-3-one 
• 138610-75-0 1-benzyl-3-t-butyl-5-chloro-2(1H)-pyrazinone 
• 173372-27-5 5-chloro-3-(1H-indol-3-yl)-1-benzyl-2(1H)-pyrazinone 
• 425669-40-5 1-benzyl-3-but-3-enyloxy-5-chloro-1H-pyrazin-2-one 
• 173199-90-1 1-benzyl-3-bromomethyl-5-chloro-2(1H)-pyrazinone 
• 428506-76-7 5-benzyl-1,3-dihydrothieno[3,4-c]pyridin-4(5H)-one 
• 428506-70-1 5-benzyl-1,3-dihydro-2,2-dioxothieno[3,4-c]pyridin-4(5H)-one 
• 428506-72-3 S¹-[(4-benzyl-4-chloro-3,4-dihydro-3-oxo-2-pyrazinyl)methyl] ethanethioate 
• 428506-74-5 1-benzyl-5-chloro-3-[(2-propynylsulfanyl)methyl]-2(1H)pyrazinone 
• 428506-81-4 5-benzyl-1,3-dihydro-3-(4-pentenyl)-2,2-dioxothieno[3,4-c]pyridin-4(5H)-one 
• 162272-99-3 2-benzyl-2,9-dihydro-β-carbolin-1-one 

Relevant articles and documents

INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Intramolecular Diels-Alder synthesis of 7-aza-α-carboline compounds

An efficient, versatile, and scalable route for the synthesis of 7-aza-α-carboline compounds is described. The tricyclic system has been prepared from modified pyrazinones using a key intramolecular [4+2] Diels-Alder transformation.

Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives

We synthesized a family of 3,5-dichloropyrazin-2(1H)-one derivatives and assessed their in vitro fungicidal activity against Candida albicans. Compounds 11 and 20 were most active against C. albicans and induced accumulation of reactive oxygen species in