87486-35-9

Usage

Uses

Used in Organic Synthesis:
1-Benzyl-3,5-dichloropyrazin-2(1H)-one is used as a key intermediate in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a versatile building block for the synthesis of complex organic molecules.
Used in Medicinal Chemistry Research:
1-Benzyl-3,5-dichloropyrazin-2(1H)-one is used as a research tool in medicinal chemistry to explore its potential pharmacological properties. It serves as a starting point for the development of new drugs with improved efficacy and selectivity.
Used in Antitumor Applications:
1-Benzyl-3,5-dichloropyrazin-2(1H)-one is used as an antitumor agent in preclinical studies. Its potential to inhibit the growth and proliferation of cancer cells has been investigated, making it a promising candidate for the development of novel anticancer therapies.
Used in Antiviral Applications:
1-Benzyl-3,5-dichloropyrazin-2(1H)-one is used as an antiviral agent in research settings. Its ability to inhibit viral replication and infectivity has been studied, with the aim of developing new antiviral drugs to combat viral diseases.
Used in Drug Development:
1-Benzyl-3,5-dichloropyrazin-2(1H)-one is used as a lead compound in drug development. Its pharmacological properties and potential therapeutic applications are being explored to design and optimize new drugs with improved safety and efficacy profiles.
It is important to handle 1-benzyl-3,5-dichloropyrazin-2(1H)-one with caution, as it may have toxic or harmful effects if not used properly. Proper safety measures and guidelines should be followed during its synthesis, storage, and application to minimize potential risks.

Upstream product

• 79-37-8 oxalyl dichloride 
• 63086-36-2 2-(benzylamino)acetonitrile hydrochloride 
• 3010-05-7 benzylaminoacetonitrile 
• 100-46-9 benzylamine 

Downstream Products

• 139268-44-3 2-Benzyl-4,6-dichloro-2,5-diaza-bicyclo[2.2.2]oct-5-en-3-one 
• 138610-74-9 1-benzyl-5-chloro-3-phenyl-2(1H)-pyrazinone 
• 98078-37-6 1-Benzyl-5-chloro-3-hydrazino-1H-pyrazin-2-one 
• 161454-88-2 1-benzyl-3-(3-butynylamino)-2(1H)-pyrazinone 
• 161454-87-1 1-benzyl-5-chloro-3-(3-butynyloxy)-2(1H)-pyrazinone 
• 173199-88-7 1-benzyl-5-chloro-3-ethyl-2(1H)-pyrazinone 
• 173199-86-5 1-benzyl-5-chloro-3-methyl-2(1H)-pyrazinone 
• 173372-27-5 5-chloro-3-(1H-indol-3-yl)-1-benzyl-2(1H)-pyrazinone 
• 216104-75-5 1-benzyl-5-chloro-3-((2-iodophenyl)amino)pyrazin-2(1H)-one 
• 425669-41-6 1-benzyl-5-chloro-3-pent-4-enyloxy-1H-pyrazin-2-one 
• 425669-40-5 1-benzyl-3-but-3-enyloxy-5-chloro-1H-pyrazin-2-one 
• 947681-70-1 methyl 3-[(4-benzyl-6-chloro-3,4-dihydro-3-oxopyrazin-2-yl)amino]propionate 
• 947681-72-3 methyl 2-[(4-benzyl-6-chloro-3,4-dihydro-3-oxo-pyrazin-2-yl)amino]-3-phenylpropionate 
• 947681-68-7 methyl [(4-benzyl-6-chloro-3,4-dihydro-3-oxopyrazin-2-yl)amino]acetate 

Relevant academic research and scientific papers

INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Scalable synthesis of functionalised 2-pyridones via [4+2] cycloaddition reactions of 2-pyrazinones and alkynylboronates

The multigram synthesis of N-protected 2-pyridone boronic acid derivatives via a [4+2] cycloaddition of alkynylboronates with 2-pyrazinones is presented. The reactions are highly chemoselective, and generally highly regioselective although trimethylsilyl-substituted alkynylboronates have proven to be an exception. Nonetheless, in this latter case, separation of regioisomers was successfully accomplished via high performance counter-current chromatography allowing isolation of analytically pure 2-pyridones. Further derivatisations of trimethylsilyl-substituted 2-pyridone boronates were performed providing access to a selection of functionalised scaffolds.

SUBSTITUTED OXAZOLIDINONES AND THEIR USE

The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases

Intramolecular Diels-Alder synthesis of 7-aza-α-carboline compounds

An efficient, versatile, and scalable route for the synthesis of 7-aza-α-carboline compounds is described. The tricyclic system has been prepared from modified pyrazinones using a key intramolecular [4+2] Diels-Alder transformation.

Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives

We synthesized a family of 3,5-dichloropyrazin-2(1H)-one derivatives and assessed their in vitro fungicidal activity against Candida albicans. Compounds 11 and 20 were most active against C. albicans and induced accumulation of reactive oxygen species in

Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position

In this paper, a synthetic approach for functionalised 5-aminopiperidinone- 2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the pot

A new synthesis of substituted 2(1H)-pyrazinones

The hydrohalides of 2-sec-aminoalkanenitriles on treatment with oxalyl halides in o-dichlorobenzene at 80-100° give 3,5-dihalo-2(1H)-pyrazinones, of which the 3-halo substituent is easily replaced by nucleophiles. A reaction mechanism for the pyrazinone s