216210-32-1Relevant academic research and scientific papers
Catalytic enantioselective alkene aminohalogenation/cyclization involving atom transfer
Bovino, Michael T.,Chemler, Sherry R.
supporting information; experimental part, p. 3923 - 3927 (2012/05/20)
Problem solved: The title reaction was used for the synthesis of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines (see scheme). Stereocenter formation is believed to occur by enantioselective cis aminocupration and C-X bond formation is believed to occur by atom transfer. The ultility of the products as versatile synthetic intermediates was demonstrated, as was a radical cascade cyclization sequence. Copyright
Synthesis of a novel series of 4,4-disubstituted 2,3,4,7-tetrahydroazepines
Barberis, Mario,García-Losada, Pablo,Pleite, Sehila,Rodríguez, Juan Ramón,Soriano, José Francisco,Mendiola, Javier
, p. 4847 - 4850 (2007/10/03)
A general, simple and straightforward strategy for the synthesis of a novel series of 4,4-disubstituted 2,3,4,7-tetrahydroazepines is described. This route involves a one-pot Wittig olefination/N-allylation process on a five-membered hemi-aminal followed by a final ring closing metathesis reaction.
Carbamoyl radicals from se-phenylselenocarbamates: Intramolecular additions to alkenes
Rigby, James H.,Danca, Diana M.,Horner, John H.
, p. 8413 - 8416 (2007/10/03)
A series of 5 exo-trig cyclizations of carbamoyl radicals generated from readily available Se-phenylselenocarbamates is reported. Kinetic studies indicate that the rate constant of this cyclization exceeds 1 x t 08s-1 in several cases.
