216237-52-4

Usage

Uses

Used in Chemical Industry:
2-Pentanamine, hydrochloride (1:1), (2S)is used as a building block in the synthesis of other organic compounds, contributing to the development of various chemical products.
Used in Pharmaceutical Industry:
2-Pentanamine, hydrochloride (1:1), (2S)is used as a pharmaceutical intermediate in the development of new drugs, leveraging its chemical properties to create innovative therapeutic agents.
Used in Aqueous Solutions and Formulations:
As a hydrochloride salt, 2-Pentanamine, hydrochloride (1:1), (2S)exhibits improved stability and solubility in water, making it suitable for use in aqueous solutions and formulations, which can enhance the delivery and effectiveness of pharmaceutical products.

Upstream product

• 109-66-0 pentane 
• 6032-29-7 (+/-)-2-pentanol 

Downstream Products

• 101689-14-9 C₁₅H₂₀F₃NO₂ 
• 101689-07-0 (R)-3,3,3-Trifluoro-2-methoxy-N-((R)-1-methyl-butyl)-2-phenyl-propionamide 
• 512847-56-2 [4-(2,4-dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methyl-butyl)-amine 

Relevant academic research and scientific papers

Asymmetric Amination of Secondary Alcohols by using a Redox-Neutral Two-Enzyme Cascade

Multienzyme cascade approaches for the synthesis of optically pure molecules from simple achiral compounds are desired. Herein, a cofactor self-sufficient cascade protocol for the asymmetric amination of racemic secondary alcohols to the corresponding chiral amines was successfully constructed by employing an alcohol dehydrogenase and a newly developed amine dehydrogenase. The compatibility and the identical cofactor dependence of the two enzymes led to an ingenious in situ cofactor recycling system in the one-pot synthesis. The artificial redox-neutral cascade process allowed the transformation of racemic secondary alcohols into enantiopure amines with considerable conversions (up to 94 %) and >99 % enantiomeric excess at the expense of only ammonia; this method thus represents a concise and efficient route for the asymmetric synthesis of chiral amines. If you know what amine: A redox-neutral two-enzyme cascade encompassing an alcohol dehydrogenase (ADH) and an amine dehydrogenase (AmDH) is constructed for the synthesis of chiral amines from the corresponding racemic alcohols in one pot to afford considerable conversions (up to 94 %) and high enantiomeric excess values (>99 %) at the expense of only ammonia.

Cerium-Catalyzed C-H Functionalizations of Alkanes Utilizing Alcohols as Hydrogen Atom Transfer Agents

Modern photoredox catalysis has traditionally relied upon metal-to-ligand charge-transfer (MLCT) excitation of metal polypyridyl complexes for the utilization of light energy for the activation of organic substrates. Here, we demonstrate the catalytic application of ligand-to-metal charge-transfer (LMCT) excitation of cerium alkoxide complexes for the facile activation of alkanes utilizing abundant and inexpensive cerium trichloride as the catalyst. As demonstrated by cerium-catalyzed C-H amination and the alkylation of hydrocarbons, this reaction manifold has enabled the facile use of abundant alcohols as practical and selective hydrogen atom transfer (HAT) agents via the direct access of energetically challenging alkoxy radicals. Furthermore, the LMCT excitation event has been investigated through a series of spectroscopic experiments, revealing a rapid bond homolysis process and an effective production of alkoxy radicals, collectively ruling out the LMCT/homolysis event as the rate-determining step of this C-H functionalization.