216239-61-1Relevant academic research and scientific papers
Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity
Henry Jr., Kenneth J.,Wasicak, James,Tasker, Andrew S.,Cohen, Jerome,Ewing, Patricia,Mitten, Michael,Larsen, John J.,Kalvin, Douglas M.,Swenson, Rolf,Ng, Shi-Chung,Saeed, Badr,Cherian, Sajeev,Sham, Hing,Rosenberg, Saul H.
, p. 4844 - 4852 (2007/10/03)
Synthesis of a library of secondary benzylic amines based on the Sebti- Hamilton type peptidomimetic farnesyltransferase (FTase) inhibitor FTI-276 (1) led to the identification of 6 as a potent enzyme inhibitor (IC50 of 8 nM) which lacked the p
