216252-68-5Relevant academic research and scientific papers
Novel arylpiperazines as selective α1-adrenergic receptor antagonists
Li, Xiaobing,Murray, William V.,Jolliffe, Linda,Pulito, Virginia
, p. 1093 - 1096 (2007/10/03)
A novel series of arylpiperazines has been synthesized and identified as antagonists of α(1a) adrenergic receptor (α(1a)-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound α(1a)-AR with K(i)s as low as 0.66 nM. As such, these potentially represent a viable treatment for BPH without the side effects associated with known α1-adrenergic antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.
