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5-(N-[(S)-N-{N,N-bis(2-chloroethyl)amino}phenoxycarbonyl-?-glutamyl]amino)isophthalic acid is a complex organic compound with the chemical formula C20H23Cl4N3O8. It is a derivative of isophthalic acid, featuring a phenoxycarbonyl group and a glutamyl moiety, both of which are crucial for its biological activity. 5-(N-[(S)-N-{N,N-bis(2-chloroethyl)amino}phenoxycarbonyl-?-glutamyl]amino)isophthalic acid is known for its cytotoxic properties and is used in the synthesis of certain anticancer drugs. Its structure includes two chloroethyl groups attached to a nitrogen atom, which contribute to its alkylating activity, and a glutamic acid residue, which plays a role in its interaction with biological targets. The compound's specific stereochemistry, indicated by the "S" configuration, is important for its biological efficacy.

216254-43-2

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216254-43-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 216254-43-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,6,2,5 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 216254-43:
(8*2)+(7*1)+(6*6)+(5*2)+(4*5)+(3*4)+(2*4)+(1*3)=112
112 % 10 = 2
So 216254-43-2 is a valid CAS Registry Number.

216254-43-2Upstream product

216254-43-2Downstream Products

216254-43-2Relevant academic research and scientific papers

Preparation of the key intermediate in a novel synthesis of ZD9063P: The chemical component of ADEPT, a targeted cytotoxic therapy

Martin, David M. G.,Siedlecki, Pawel S.

, p. 259 - 263 (2000)

A novel regioselective opening of the cyclic anhydride of a urethane derivative of glutamic acid using 4-(dimethylamino)-pyridine (DMAP) as the catalyst has greatly simplified the synthesis of the target compound, ZD9063P, 5-(N-[(S)-N-{N,N-bis(2-chloroeth

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