Preparation of the key intermediate in a novel synthesis of ZD9063P: The chemical component of ADEPT, a targeted cytotoxic therapy

Article abstract of DOI:10.1021/op000016+

A novel regioselective opening of the cyclic anhydride of a urethane derivative of glutamic acid using 4-(dimethylamino)-pyridine (DMAP) as the catalyst has greatly simplified the synthesis of the target compound, ZD9063P, 5-(N-[(S)-N-{N,N-bis(2-chloroeth