21626-41-5

Basic information

• Product Name: 2-N-BenzylaMino-5-nitropyridine
• Synonyms: 2-N-BenzylaMino-5-nitropyridine
• CAS NO: 21626-41-5
• Molecular Formula: C₁₂H₁₁N₃O₂
• Molecular Weight: 229.23464
• Mol File: 21626-41-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 398.9°C at 760 mmHg
• Flash Point: 195°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 1.43E-06mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 2-N-BenzylaMino-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-N-BenzylaMino-5-nitropyridine(21626-41-5)
• EPA Substance Registry System: 2-N-BenzylaMino-5-nitropyridine(21626-41-5)

Safety Data

• Hazardous Substances Data: 21626-41-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11N3O2/c16-15(17)11-6-7-12(14-9-11)13-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,13,14)

Upstream product

• 2530-26-9 3-nitropyridine 
• 100-46-9 benzylamine 
• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 100-51-6 benzyl alcohol 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 21630-48-8 N-2-benzylpyridine-2,5-diamine 

Relevant articles and documents

Water-promoted dehydrative coupling of 2-aminopyridines in heptane: Via a borrowing hydrogen strategy

A synthetic method for dehydrative N-benzylation promoted by water molecules in heptane using a π-benzylpalladium system has been developed. The presence of water significantly accelerates carbon-nitrogen bond formation, which is accomplished in an atom-economical process to afford the corresponding N-monobenzylated products. A crossover experiment afforded H/D scrambled products, which is consistent with a borrowing hydrogen mechanism. Kinetic isotope effect measurements revealed that benzylic carbon-hydrogen bond cleavage was the rate-determining step.

C-N bond formation by the oxidative alkylamination of azines: Comparison of AgPy2MnO4 versus KMnO4 as oxidant

Reports on the successful oxidative alkylamination of azines by the S NH-reaction, with the use of alkylamines other than methylamine, are very scarce. Hitherto, the experimental limitation to extend oxidative animation of azines wit

Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands

The present invention encompasses structures of the Formula or the pharmaceutically acceptable non-toxic salts thereof wherein: x is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.