21626-69-7

Basic information

• Product Name: N-[4-(4-morpholinylsulphonyl)phenyl]acetamide
• Synonyms: N-[4-(4-morpholinylsulphonyl)phenyl]acetamide;Einecs 244-483-8;4'-(Morpholinylsulfonyl)acetanilide, 97%
• CAS NO: 21626-69-7
• Molecular Formula: C₁₂H₁₆N₂O₄S
• Molecular Weight: 284.33144
• EINECS: 244-483-8
• Mol File: 21626-69-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.361g/cm³
• Refractive Index: 1.592
• CAS DataBase Reference: N-[4-(4-morpholinylsulphonyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(4-morpholinylsulphonyl)phenyl]acetamide(21626-69-7)
• EPA Substance Registry System: N-[4-(4-morpholinylsulphonyl)phenyl]acetamide(21626-69-7)

Safety Data

• Hazardous Substances Data: 21626-69-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16N2O4S/c1-10(15)13-11-2-4-12(5-3-11)19(16,17)14-6-8-18-9-7-14/h2-5H,6-9H2,1H3,(H,13,15)

Upstream product

• 103-84-4 Acetanilid 
• 1939-89-5 N-(4-(morpholinodiazenyl)phenyl)acetamide 
• 110-91-8 morpholine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 122-80-5 N-acetyl-p-phenylenediamine 

Downstream Products

• 93345-15-4 N-{4-[4-(Morpholine-4-sulfonyl)-phenylsulfamoyl]-phenyl}-acetamide 
• 21626-70-0 4-(morpholinosulfonyl)aniline 

Relevant articles and documents

Ammonium chloride-catalyzed four-component sonochemical synthesis of novel hexahydroquinolines bearing a sulfonamide moiety

Ammonium chloride as a very inexpensive and readily available reagent efficiently catalyzes one-pot four-component condensation of dimedone with aromatic aldehyde, malononitrile or ethyl cyanoacetate, and sulfonamide derivatives in ethanol at 70°C under ultrasonic irradiation to afford the corresponding 2-amino-4-aryl-1,4,5,6,7,8-hexahydroquinolines bearing a sulfonamide moiety in high yields. In comparison to conventional methods, high yields, easy work-up, and short reaction time are advantages of this sonochemical procedure. The effects of the catalyst, solvent, and temperature are assessed.

Catalytic conversion of aryl triazenes into aryl sulfonamides using sulfur dioxide as the sulfonyl source

Various sulfonamides have been synthesized from triazenes and sulfur dioxide. In the presence of just a catalytic amount of BF3· OEt2, a series of 1-aryl-triazenes were converted into sulfonyl hydrazines in good to excellent yields. When using CuCl2 as the catalyst, the corresponding sulfonamides can be produced from the 1-aryl triazenes in good yields. This journal is the Partner Organisations 2014.

NOVEL ADENOSINE A3 RECEPTOR AGONISTS

The invention realizes that a series of sulfonamido derivatives with a conserved uronamide group at the 5' position provide superior A3 receptor affinity as well as selectivity. These new adenosine agonists are sulfonamido deritatives N-substituted with aliphatic groups (cyclic or linear) or aromatic radicals.