216260-05-8

Upstream product

• 203576-71-0 benzyl (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-oxo-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate 
• 216260-03-6 ceanothic acid dibenzyl ester 
• 100-44-7 benzyl chloride 
• 2739-72-2 ceanothic acid 
• 216260-04-7 3-oxo-ceanothic acid dibenzyl ester 

Downstream Products

• 216260-06-9 1-decarboxy-ceanothic acid benzyl ester 

Relevant academic research and scientific papers

AZA-SUBSTITUTED INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, aza-substituted triterpenoid compounds that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula (I). These compounds are useful for the treatment of HIV and AIDS.

Preparation and cytotoxic effect of ceanothic acid derivatives

Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.