216260-06-9Relevant academic research and scientific papers
Preparation and cytotoxic effect of ceanothic acid derivatives
Lee, Shoei-Sheng,Chen, Wen-Chuan,Huang, Chih-Fen,Su, Yeu
, p. 1343 - 1347 (2007/10/03)
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.
