21627-59-8

Upstream product

• 21627-60-1 N₁,N₁-Dimethyl-N₃-(2-nitrophenyl)-1,3-propanediamine 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 109-55-7 1-amino-3-(dimethylamino)propane 

Downstream Products

• 78155-88-1 1-dimetilamminopropil-3-metilchinossalin-2(1H)-one 
• 117928-83-3 3-benzyl-1-dimethylaminopropyl-quinoxalin-2(1H)one 
• 600724-57-0 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid {(R)-2-(3,5-dibromo-4-hydroxy-phenyl)-1-[1-(3-dimethylaminopropyl)-1H-benzimidazol-2-yl]-ethyl}-amide 
• 600724-78-5 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid {2-(3,5-bis-trifluoromethyl-phenyl)-1-[1-(3-dimethylaminopropyl)-1H-benzimidazol-2-yl]-ethyl}-amide 
• 600724-85-4 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid {2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-[1-(3-dimethylaminopropyl)-1H-benzimidazol-2-yl]-ethyl}-amide 
• 600724-86-5 3-(1-{4-(3,4-diethyl-phenyl)-3-[1-(3-dimethylaminopropyl)-1H-benzimidazol-2-yl]-butyryl}-piperidin-4-yl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one 
• 1023698-55-6 {3-[2-(2-chloro-phenoxymethyl)-benzimidazol-1-yl]-propyl}-dimethyl-amine 
• 105143-51-9 1-(3-dimethylamino-propyl)-1H-benzimidazole 
• 1023698-54-5 C₁₉H₂₂BrN₃ 
• 20904-16-9 dimethyl-[3-(2-phenoxymethyl-benzoimidazol-1-yl)-propyl]-amine 
• 1023698-52-3 {3-[2-(2-fluoro-benzyl)-benzimidazol-1-yl]-propyl}-dimethyl-amine 
• 1023698-57-8 {3-[2-(4-fluoro-phenoxymethyl)-benzimidazol-1-yl]-propyl}-dimethyl-amine 
• 1023698-58-9 dimethyl-[3-(2-p-tolyloxymethyl-benzimidazol-1-yl)-propyl]-amine 
• 1023698-53-4 {3-[2-(2-methoxy-benzyl)-benzimidazol-1-yl]-propyl}-dimethyl-amine 

Relevant academic research and scientific papers

Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations into th

Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[ a[phenazin derivatives as dual topoisomerase I/II inhibitors

A novel series of benzo[a]phenazin derivatives bearing alkylamino side chains were designed, synthesized and evaluated for their topoisomerases inhibitory activity as well as cytotoxicity against four human cancer cell lines (HL-60, K-562, HeLa, and A549)

Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivity

A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.

Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles

Alpha7 agonists were identified via GOLD (CCDC) docking in the putative agonist binding site of an alpha7 homology model and a series of aminoalkyl benzoimidazoles was synthesised to obtain potentially brain penetrant drugs. The array was prepared startin

Multi-cyclic compound and method of use

The present invention relates to chemical compounds having a general formula I wherein A, B, C1, C2, D, L1, L2 and R3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

Benzimidazole derivative, hair growth promoter and external composition for skin using the same

A benzimidazole derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30expressed by R1and the other is —(CH2)n—NR2R3; R

Cyclopenta[e][1,5] benzodiazepin-10 (9H)-one derivatives as CNS depressant agents

A series of dialkylaminoalkyl derivatives of cyclopenta[e][1,5] benzodiazepin-10(9H)-one (E1-4) and its 6-chloro derivative (E5-8) was prepared to evaluate their CNS activity in comparison with that of isosteric pyridodiazepinones (A