21629-48-1 Usage
General Description
7-Chloro-2,8-dimethyl-4-quinolinol is a chemical compound with the molecular formula C11H10ClNO. It is a quinoline derivative with a chlorine atom at the 7th position and methyl groups at the 2nd and 8th positions. 7-CHLORO-2,8-DIMETHYL-4-QUINOLINOL is commonly used in organic synthesis and pharmaceutical research due to its versatile reactivity and potential pharmacological properties. It has been studied for its antibacterial, antifungal, and antiviral activities, making it a promising candidate for drug development. Additionally, 7-Chloro-2,8-dimethyl-4-quinolinol has also been investigated for its potential use in agrochemicals and as a chelating agent in analytical chemistry. Overall, this chemical compound has a wide range of applications and continues to be an important target for research and development in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 21629-48-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,2 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21629-48:
(7*2)+(6*1)+(5*6)+(4*2)+(3*9)+(2*4)+(1*8)=101
101 % 10 = 1
So 21629-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H10ClNO/c1-6-5-10(14)8-3-4-9(12)7(2)11(8)13-6/h3-5H,1-2H3,(H,13,14)
21629-48-1Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.
