21728-15-4 Usage
General Description
4,7-Dichloro-2,8-dimethylquinoline is an organic compound with the molecular formula C11H10Cl2N. It is a quinoline derivative that contains two chlorine atoms and two methyl groups attached to the quinoline ring. This chemical is used as a pesticide and is known for its ability to control a wide range of pests including aphids, caterpillars, and mites. It is often used in agricultural settings as a crop protectant. Additionally, 4,7-dichloro-2,8-dimethylquinoline has been studied for its potential use in the pharmaceutical industry, particularly for its anti-tumor and anti-inflammatory properties. However, it also poses potential health and environmental risks due to its toxicity and persistence in the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 21728-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,2 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 21728-15:
(7*2)+(6*1)+(5*7)+(4*2)+(3*8)+(2*1)+(1*5)=94
94 % 10 = 4
So 21728-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H9Cl2N/c1-6-5-10(13)8-3-4-9(12)7(2)11(8)14-6/h3-5H,1-2H3
21728-15-4Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.
