2162939-89-9

Usage

Uses

Used in Asymmetric Catalysis:
(R)-N-((R)-1-(5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)-2,2-dimeth ylpropyl)-2-methylpropane-2-sulfinamide is used as a chiral catalyst for facilitating asymmetric reactions in the field of organic chemistry. Its unique structure and chiral center enable it to induce selectivity in chemical reactions, leading to the formation of enantiomerically enriched products.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, (R)-N-((R)-1-(5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)-2,2-dimeth ylpropyl)-2-methylpropane-2-sulfinamide is used as a potential candidate for the development of new drugs. Its complex structure and functional groups may offer novel interactions with biological targets, potentially leading to the discovery of new therapeutic agents.
Further research and investigation are required to fully understand the properties and potential applications of (R)-N-((R)-1-(5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)-2,2-dimeth ylpropyl)-2-methylpropane-2-sulfinamide, as its complex nature suggests a wide range of possibilities in various chemical and pharmaceutical industries.

Upstream product

• 630-19-3 pivalaldehyde 
• 19814-75-6 9,9-dimethylxanthene 
• 1079-66-9 chloro-diphenylphosphine 
• 182153-21-5 ?4,5-diiodo-9,9-dimethylxanthene 

Relevant academic research and scientific papers

Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications

Herein we reported an efficient palladium-catalyzed enantioselective arylation of both alkyl and aryl sulfenate anions to deliver various chiral sulfoxides in good yields (up to 98%) with excellent enantioselectivities (up to 99% ee) by the use of our developed chiral O,P-ligands (PC-Phos). PC-Phos are easily prepared in short steps from inexpensive commercially available starting materials. The single-crystal structure of the PC4/PdCl2 showed that a rarely observed 11-membered ring was formed via the O,P-coordination with the palladium(II) center. The salient features of this method include general substrate scope, ease of scale-up, applicable to the late-stage modification of bioactive compounds, and the synthesis of a marketed medicine Sulindac.

Based on xanthene skeleton of PC - Phos chiral shan lin ligands and its full configuration of the preparation method and application (by machine translation)

The invention discloses a xanthene skeleton model PC - Phos monophosphine ligand, the ligands of formula (1) compounds of formula or its enantiomer, racemate or non-enantiomer The invention also discloses the preparation method of the ligand, in order to type 2 Formula 4 As raw materials, the substitution reaction, addition reaction, condensation reaction, the reduction reaction of the preparation to the ligand; intercept a 6 Formula 4 As the raw material, a condensation reaction, and The addition reaction to the ligand. The present invention through the use of two configurations deodoration sulfonamide 4 and different types of metal reagent addition reaction, can be obtained by the ligand states chiral shan lin 1 (S, Rs ), 1 (R, Rs ), 1 (S, Ss ) And 1 (R, Ss ) Of four full-configuration of optically pure. The invention also discloses the ligands catalytic connected enamine in the molecule in the asymmetric cyclization reaction of application, has very high reaction activity and stereo selectivity, has wide application value. (by machine translation)