2163-34-0

Basic information

• Product Name: 4-TERT-BUTYLCYCLOHEXANAMINE
• Synonyms: 4-TERT-BUTYLCYCLOHEXANAMINE;Trans-4-(Tert-Butyl)Cyclohexanamine;Cyclohexanamine, 4-(1,1-dimethylethyl)-, trans-;Trans-4-(Tert-Butyl)Cyclohexanamine(WXC00784)
• CAS NO: 2163-34-0
• Molecular Formula: C₁₀H₂₁N
• Molecular Weight: 155.28044
• Mol File: 2163-34-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 81-83 °C
• Boiling Point: 142-145 °C(Press: 19 Torr)
• Appearance: /
• Density: 0.861±0.06 g/cm3(Predicted)
• PKA: 10.58±0.70(Predicted)
• CAS DataBase Reference: 4-TERT-BUTYLCYCLOHEXANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYLCYCLOHEXANAMINE(2163-34-0)
• EPA Substance Registry System: 4-TERT-BUTYLCYCLOHEXANAMINE(2163-34-0)

Safety Data

• Hazardous Substances Data: 2163-34-0(Hazardous Substances Data)

Upstream product

• 4701-98-8 4-tert-butylcyclohexanone oxime 
• 67498-86-6 trans-4-tert-butylcyclohexylbenzylamine 
• 344869-42-7 N-(4-tert-butylcyclohexyl)benzylamine 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 943-27-1 4'-t-butylacetophenone 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 943-29-3 trans-4-(tert-butyl)cyclohexane-1-carboxylic acid 
• 98-54-4 para-tert-butylphenol 

Downstream Products

• 101866-18-6 2-[(trans-4-tert-Butyl-cyclohexylimino)-methyl]-phenol 
• 72087-46-8 N-Acetyl-N-m-chlorbenzoyl-trans-4-tert.-butylcyclohexylamin 
• 78193-51-8 1-(4-tert-Butyl-cyclohexyl)-3-(2,2,2-trichloro-acetyl)-urea 
• 161465-33-4 ethyl trans-N-<4-(1,1-dimethylethyl)cyclohexyl>aminoacetate 
• 2523-69-5 trans-4-t-butyl-N,N-dimethylcyclohexylamine 
• 61965-95-5 N-(4-tert-Butyl-cyclohexyl)-3,3-diphenyl-propionamide 
• 13991-73-6 C₁₃H₂₄ClN₃O₂ 
• 127456-43-3 Trans-2-(4'-tert-butylcyclohexylamino)-methyl-4-tertpentylphenol 
• 21862-63-5 trans-4-tert-butylcyclohexanol 
• 937-05-3 cis-4-tert-butyl-1-cyclohexanol 
• 1900-69-2 trans-4-tert-butylcyclohexyl acetate 
• 10411-92-4 cis-4-tert-butylcyclohexyl acetate 
• 85136-35-2 3,3-Dimethyl-butyric acid 4-tert-butyl-cyclohexyl ester 
• 85136-35-2 3,3-Dimethyl-butyric acid 4-tert-butyl-cyclohexyl ester 

Relevant articles and documents

6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS

The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series.

Aliphatic C-H Bond Oxidation with Hydrogen Peroxide Catalyzed by Manganese Complexes: Directing Selectivity through Torsional Effects

Substituted N-cyclohexyl amides undergo aliphatic C-H bond oxidation with H2O2 catalyzed by manganese complexes. The reactions are directed by torsional effects leading to site-selective oxidation of cis-1,4-, trans-1,3-, and cis-1,2-cyclohexanediamides. The corresponding diastereoisomers are unreactive under the same conditions. Competitive oxidation of cis-trans mixtures of 4-substituted N-cyclohexylamides leads to quantitative conversion of the cis-isomers, allowing isolation and successive conversion of the trans-isomers into densely functionalized oxidation products with excellent site selectivity and good enantioselectivity.