943-29-3

Usage

Chemical Properties

white fine crystalline powder

InChI:InChI=1/C11H20O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h8-9H,4-7H2,1-3H3,(H,12,13)/t8-,9-

Upstream product

• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 124-38-9 carbon dioxide 
• 5009-36-9 cis-1-bromo-4-tert-butylcyclohexane 
• 201230-82-2 carbon monoxide 
• 3178-22-1 tert-butylcyclohexane 
• 19091-08-8 methyl 4-tert-butyl-cyclohexanecarboxylate 
• 98-52-2 4-(1,1-dimethylethyl)-cyclohexanol 
• 5451-55-8 4-tert-butylcyclohexanecarboxylic acid 
• 943-27-1 4'-t-butylacetophenone 
• 943-28-2 cis-4-t-butylcyclohexanecarboxylic acid 
• 114297-17-5 methyl trans-3-tert-butylcyclohexanecarboxylate 

Downstream Products

• 5009-37-0 trans-1-bromo-4-tert-butylcyclohexane 
• 5009-36-9 cis-1-bromo-4-tert-butylcyclohexane 
• 2163-34-0 trans-4-t-butylcyclohexylamine 
• 15619-10-0 trans-1-(4'-t-butylcyclohexyl)-1-ethanone 
• 907-04-0 bis-(trans-4-tert-butyl-cyclohexanecarbonyl)-peroxide 
• 10601-39-5 trans-(4-tert-butyl-cyclohexyl)-methanol 
• 28467-42-7 trans-4-t-butylcyclohexanecarbonyl chloride 
• 17177-75-2 methyl ester of trans-4-tert-butylcyclohexanecarboxylic acid 
• 29708-15-4 acide t.butyl-4 cyclohexane peroxycarboxylique trans 
• 27069-57-4 1-Methyl-trans-4-tert-butylcyclohexanecarboxylic acid 
• 31752-57-5 1-Methyl-cis-4-tert-butylcyclohexanecarboxylic acid 
• 15619-12-2 trans-4-tert.-Butyl-<2-hydroxypropyl-(2)>-cyclohexan 
• 15619-14-4 trans-4-tert.-Butyl-1-propionylcyclohexan 
• 19461-35-9 trans-4-(tert-butyl)cyclohexylmethyl acetate 

Relevant academic research and scientific papers

Electrocatalytic hydrogenation of benzoic acids in a proton-exchange membrane reactor

The highly efficient chemoselective electrocatalytic hydrogenation of benzoic acids (BAs) to cyclohexanecarboxylic acids (CCAs) was carried out in a proton-exchange membrane reactor under mild conditions without hydrogenation of the carboxyl group. Among the investigated catalysts, the PtRu alloy catalyst was found to be the most suitable for achieving high current efficiencies for production of CCAs. An electrochemical spillover mechanism on the PtRu alloy catalyst was also proposed.

Nickel- and cobalt-catalyzed direct alkylation of azoles with N-tosylhydrazones bearing unactivated alkyl groups

A matter of catalyst: Azole compounds can be directly alkylated with N-tosylhydrazones that bear unactivated alkyl groups (see scheme; phen=1,10-phenanthroline, Ts=p-toluenesulfonyl). Nickel catalysis enables the introduction of simple secondary alkyl chains into benzoxazole compounds, whereas the alkylation of 5-aryloxazoles and benzothiazole is possible by using a cobalt catalyst. Copyright

5-ETHYL-IMIDAZO (5,1-F) (1,2,4,) TRIAZIN-4 (3H) -ONES AS PHOSPHODIESTERASE INHIBITORS

The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Separation of cis/trans-cyclohexanecarboxylates by enzymatic hydrolysis: Preference for diequatorial isomers

4-Substituted cis/trans-cyclohexanecarboxylates have been separated into the isomers by enzymatic hydrolysis with lipase from Candida rugosa with very good selectivity. The enzyme preferentially recognizes diequatorial conformations. Copyright (C) 1996 Elsevier Science Ltd.

Pd-Catalyzed Regio- and Stereo-selective Carboxylation of Cycloalkanes with CO

The reactions of cycloalkanes with CO via the C-H bond activation by Pd(OAc)2 catalyst have been found to proceed regio- and stereo-selectively to give corresponding carboxylic acids.The reactivity of C-H bonds of cycloalkanes decreases in the order: tert- > sec- > prim-carbon, and the stereochemistry of the substitutents on the main products is all equatorial.

N-(Cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. 2

A series of analogues of N-(cyclohexylcarbonyl)-D-phenylalanine (5) have been synthesized and evaluated for their hypoglycemic activity. Relationships were studied between the activity and the three-dimensional structure of the acyl moiety, which was characterized by high-resolution 1H NMR spectroscopy and MNDO calculations. The role of the carboxyl group of the phenylalanine moiety was also studied by comparing the activities of the enantiomers, the decarboxyl derivative, the esters, and the amides of the phenylalanine derivatives. Thus, the structural requirements for possessing hypoglycemic activity was elucidated and a highly active compound, N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine (13) was obtained, which showed a 20% blood glucose decrease at an oral dose of 1.6 mg/kg in fasted normal mice.

Antiprotozoal compounds

1,4-Naphthoquinones of formula (I), methods for their preparation, veterinary formulations thereof, and the use thereof in animal therapy are disclosed. STR1 Particularly preferred compounds of formula (I) are, 2-[trans-(4-t-butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone, and 2-[trans-(4-t-pentyl cyclohexyl)methyl]3-hydroxy-1,4-naphthoquinone. The compounds are of value as anti-protozoal agents, in particular as anti-theilerial agents.

Stereoelectronic Effects in Hydrogen-atom Transfer Reactions of Substituted Cyclohexyl Radicals

Thermolysis of the peroxyoxalates (1)-(7) and the diacyl peroxides (8)-(11) in cyclohexane at 100 deg C gives cycloalkenes and cycloalkanes by hydrogen-atom transfer reactions of the initially formed conformationally biased 4-t-butyl-, 4-t-butyl-cis,cis-2,6-dimethyl-, 4-t-butyl-cis,trans-2,6-dimethyl-, 4-t-butyl-cis-2-methyl-, 4-t-butyl-trans-2-methyl-, and 5-t-butyl-cis-2-methylcyclohexyl radicals (12)-(17).The composition of the product mixtures indicates that transfer of axial β-hydrogen atoms occurs more rapidly than does transfer of equatorial β-hydrogen atoms.These results support the hypothesis that homolytic fission of a C-H bond is favoured when it lies chlose to the plane of an adjacent semi-occupied orbital.