216302-09-9Relevant articles and documents
Synthesis of a new dual metalloprotease inhibitor. II. Stereoselective synthesis of peptidomimetic [5.7]-bicyclic compounds
Akasaka, Kozo,Komatsu, Yuki,Tagami, Katsuya,Shimizu, Toshikazu,Shimomura, Naoyuki,Naka, Hiroshi,Hayashi, Kenji,Negi, Shigeto
, p. 1532 - 1537 (2007/10/03)
An efficient synthetic process for the key intermediate of a new peptidomimetic dual metalloprotease inhibitor, ER-40133, was developed. (5R)- Methyl-6-oxopipecolic acid ester (3a), prepared from L-α,-aminoadipic acid, was chemoselectively reduced to the