216314-74-8Relevant academic research and scientific papers
Total synthesis of topsentin, antiviral and antitumor bis(indolyl)imidazole
Kawasaki, Ikuo,Katsuma, Hideo,Nakayama, Yohko,Yamashita, Masayuki,Ohta, Shunsaku
, p. 1887 - 1901 (2007/10/03)
Topsentin (1), which was isolated from marine sponges and has antiviral and antitumor activities, was synthesized via a cross coupling reaction in the presence of palladium catalyst at the 5-position and an acylation at the 2-position of imidazole ring.
